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撤回:MicroRNA-381 通过抑制 RELN 介导的 PI3K/AKT/mTOR 信号通路促进前列腺癌细胞自噬和凋亡。

RETRACTED: MicroRNA-381 facilitates autophagy and apoptosis in prostate cancer cells via inhibiting the RELN-mediated PI3K/AKT/mTOR signaling pathway.

机构信息

Department of Urology, Renmin Hospital of Wuhan University, Wuhan 430000, PR China.

Department of Urology, People's Hospital of Hanchuan, Hanchuan 431600, PR China.

出版信息

Life Sci. 2020 Aug 1;254:117672. doi: 10.1016/j.lfs.2020.117672. Epub 2020 Apr 15.

Abstract

This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of the Editor-in-Chief. Concern was raised about the reliability of the Western blot results in Figures 5B+D, 6B+D, 7B+D, and 8C, which appear to have a similar phenotype as many other publications, as detailed here: https://pubpeer.com/publications/70795908CC4CEFC1753E19583700F4; and here: https://docs.google.com/spreadsheets/d/1r0MyIYpagBc58BRF9c3luWNlCX8VUvUuPyYYXzxWvgY/edit#gid=262337249. In addition, a portion of Figure 6C, ‘miR-381 mimic’ group appeared to contain image similarities with Figure 6C, ‘si-RELN’ group. The journal requested that the corresponding author comment on these concerns and provide the raw data. The authors did not respond to this request and therefore the Editor-in-Chief decided to retract the article.

摘要

本文已被撤回

请参阅爱思唯尔撤稿政策(http://www.elsevier.com/locate/withdrawalpolicy)。应主编要求,撤回本文。对图 5B+D、6B+D、7B+D 和 8C 中的 Western blot 结果的可靠性提出了质疑,这些结果似乎与许多其他出版物具有相似的表型,详见:https://pubpeer.com/publications/70795908CC4CEFC1753E19583700F4;以及此处:https://docs.google.com/spreadsheets/d/1r0MyIYpagBc58BRF9c3luWNlCX8VUvUuPyYYXzxWvgY/edit#gid=262337249。此外,图 6C 的“miR-381 mimic 组”似乎与图 6C 的“si-RELN 组”存在图像相似之处。期刊要求通讯作者对这些问题发表评论并提供原始数据。作者未对此请求作出回应,因此主编决定撤回该文章。

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