Princeton Neuroscience Institute, Princeton, United States.
Department of Psychology, Princeton University, Princeton, United States.
Elife. 2022 Apr 8;11:e70445. doi: 10.7554/eLife.70445.
Schematic prior knowledge can scaffold the construction of event memories during perception and also provide structured cues to guide memory search during retrieval. We measured the activation of story-specific and schematic representations using fMRI while participants were presented with 16 stories and then recalled each of the narratives, and related these activations to memory for specific story details. We predicted that schema representations in medial prefrontal cortex (mPFC) would be correlated with successful recall of story details. In keeping with this prediction, an anterior mPFC region showed a significant correlation between activation of schema representations at encoding and subsequent behavioral recall performance; however, this mPFC region was not implicated in schema representation during retrieval. More generally, our analyses revealed largely distinct brain networks at encoding and retrieval in which schema activation was related to successful recall. These results provide new insight into when and where event knowledge can support narrative memory.
图式先验知识可以在感知过程中为事件记忆的构建提供支撑，也可以为记忆检索提供结构化线索，以引导记忆搜索。我们使用 fMRI 测量了参与者在观看 16 个故事时特定故事和图式表示的激活情况，然后让他们回忆每个故事，并将这些激活与特定故事细节的记忆相关联。我们预测内侧前额叶皮层（mPFC）中的图式表示与成功回忆故事细节相关。与这一预测一致，mPFC 的一个前区显示出在编码时图式表示的激活与随后的行为回忆表现之间存在显著相关性；然而，该 mPFC 区域在检索时并未涉及图式表示。更一般地，我们的分析揭示了在编码和检索时大脑网络的明显差异，其中图式激活与成功回忆有关。这些结果为事件知识何时以及何地能够支持叙事记忆提供了新的见解。
