Department of Sport Medicine and Functional Explorations, Diet and Musculoskeletal Health Team, Human Nutrition Research Center (CRNH), INRA, University Teaching Hospital of Clermont-Ferrand, University of Clermont Auvergne, 63000 Clermont-Ferrand, France.
Department of Pediatrics, Paracelsus Medical University, 5020 Salzburg, Austria.
Nutrients. 2021 Dec 24;14(1):60. doi: 10.3390/nu14010060.
Metabolic syndrome (MetS) is highly prevalent in children and adolescents with obesity and places them at an increased risk of cardiovascular-related diseases. However, the associations between objectively measured movement-related behaviors and MetS diagnosis remain unexplored in youths with obesity. The aim was to compare profiles of sedentary (SED) time (more sedentary, SED+ vs. less sedentary, SED-), moderate to vigorous physical activity (MVPA) time (more active, MVPA+ vs. less active, MVPA-) and combinations of behaviors (SED-/MVPA+, SED-/MVPA-, SED+/MVPA+, SED+/MVPA-) regarding the MetS diagnosis. One hundred and thirty-four adolescents with obesity (13.4 2.2 years) underwent 24 h/7 day accelerometry, waist circumference (WC), blood pressure (BP), high-density lipoprotein-cholesterol (HDL-c), triglycerides (TG) and insulin-resistance (IR) assessments. Cumulative cardiometabolic risk was assessed by using (i) MetS status (usual dichotomic definition) and (ii) cardiometabolic risk z-score (MetScore, mean of standardized WC, BP, IR, TG and inverted HDL-c). SED- vs. SED+ and MVPA+ vs. MVPA- had lower MetS ( < 0.01 and < 0.001) and MetScore ( < 0.001). SED-/MVPA+ had the lowest risk. While SED and MVPA times were lower in SED-/MVPA- vs. SED+/MVPA+ ( < 0.001), MetScore was lower in SED-/MVPA- independently of body mass index (BMI) ( < 0.05). MVPA, but not SED, time was independently associated with MetS diagnosis ( < 0.05). Both MVPA ( < 0.01) and SED times ( < 0.05) were associated with MetScore independently of each other. A higher MVPA and lower SED time are associated with lower cumulative cardiometabolic risk.
代谢综合征（MetS）在肥胖的儿童和青少年中非常普遍，使他们患心血管相关疾病的风险增加。然而，在肥胖青少年中，客观测量的与运动相关的行为与 MetS 诊断之间的关联仍未得到探索。本研究旨在比较久坐时间（更多久坐，SED+ 与更少久坐，SED-）、中等到剧烈体力活动（MVPA）时间（更活跃，MVPA+ 与不活跃，MVPA-）以及行为组合（SED-/MVPA+、SED-/MVPA-、SED+/MVPA+、SED+/MVPA-）与 MetS 诊断的关系。134 名肥胖青少年（13.4±2.2 岁）接受了 24 小时/7 天加速度计、腰围（WC）、血压（BP）、高密度脂蛋白胆固醇（HDL-c）、甘油三酯（TG）和胰岛素抵抗（IR）评估。采用（i）MetS 状态（通常的二分定义）和（ii）心血管代谢风险 Z 评分（MetScore，WC、BP、IR、TG 和倒置 HDL-c 标准化的平均值）评估累积心血管代谢风险。SED- 与 SED+ 和 MVPA+ 与 MVPA-的 MetS（<0.01 和 <0.001）和 MetScore（<0.001）较低。SED-/MVPA+ 的风险最低。虽然 SED- 和 MVPA- 时间在 SED-/MVPA- 与 SED+/MVPA+ 之间较低（<0.001），但 MetScore 在 SED-/MVPA- 中独立于体重指数（BMI）（<0.05）较低。MVPA 而不是 SED 时间与 MetS 诊断独立相关（<0.05）。MVPA（<0.01）和 SED 时间（<0.05）均与 MetScore 独立相关。较高的 MVPA 和较低的 SED 时间与较低的累积心血管代谢风险相关。
