Vogel J J, de Moerloose P A, Bounameaux H
Hemostasis Unit, University Hospital of Geneva, Switzerland.
Obstet Gynecol. 1989 Mar;73(3 Pt 2):455-6.
Protein C is thought to play a key role in the regulation of hemostasis, and its deficiency has been associated with an increased risk of thromboembolism. Protein C-deficient women are at particular risk of developing thromboembolic complications during pregnancy and delivery. The incidence of thromboembolic events is estimated to be 500-1000 times higher than in normal women. We report the case of a 26-year-old woman with previous iliofemoral deep vein thrombosis who experienced a successful pregnancy and delivery despite severe congenital protein C deficiency (protein C antigen and activity 25%). She was anticoagulated with heparin during the second part of her pregnancy. Our observation suggests that ambulatory full-dose subcutaneous heparin therapy during pregnancy constitutes adequate prevention. However, definite guidelines will require more extensive studies.
蛋白C被认为在止血调节中起关键作用，其缺乏与血栓栓塞风险增加有关。蛋白C缺乏的女性在妊娠和分娩期间发生血栓栓塞并发症的风险尤其高。据估计，血栓栓塞事件的发生率比正常女性高500 - 1000倍。我们报告一例26岁女性病例，该女性既往有髂股深静脉血栓形成，尽管患有严重的先天性蛋白C缺乏症（蛋白C抗原和活性为25%），但仍成功妊娠并分娩。她在妊娠后期接受了肝素抗凝治疗。我们的观察表明，妊娠期间门诊全剂量皮下肝素治疗构成了充分的预防措施。然而，明确的指南将需要更广泛的研究。
