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[遗传性抗凝血酶III缺乏症。1例产科病例报告及文献复习]

[Hereditary antithrombin III deficiency. Report of an obstetric case and review of the literature].

作者信息

Leal-Tijerina G, Alvarado-Barrientos M, Sosa-Gillaumin A

出版信息

Ginecol Obstet Mex. 1996 Apr;64:177-83.

PMID:8698247
Abstract

This case is a gravida 2, para 1, 21 years old, with a 36 weeks pregnancy, complicated with light toxemia, hereditary Antithrombin III (AT III) deficiency, and left iliofemoral thrombophlebitis; the patient was in labor. Two family members had thromboembolic phenomena, one of them had died because of this. The patient have had thrombophlebitis in both lower limbs during the puerperium of her previous delivery. She had received anticoagulants irregularly. Four months before the diagnosis of hereditary AT III deficiency, by laboratory. Labor was normal and had an eutocic delivery, masculine product, 3,250 g, without complications. Three hours before the effect of heparin had been reverted with protamine sulphate. Eight hours after delivery administration of heparin, was reestablished. The patient did not present other complications, and was discharged nine days after delivery. The literature about this subject was reviewed. Special emphasis is given to treatment alternatives in this type of disease that produce hypercoagulability and thromboembolic phenomena. This is the first report in Mexican literature.

摘要

该病例为一名21岁孕妇,孕2产1,妊娠36周,合并轻度子痫前期、遗传性抗凝血酶III(AT III)缺乏症及左髂股静脉血栓性静脉炎;患者正在分娩。两名家庭成员有血栓栓塞现象,其中一人因此死亡。该患者在上次分娩的产褥期双下肢均发生过血栓性静脉炎。她曾不规则使用抗凝剂。在通过实验室诊断遗传性AT III缺乏症前四个月。分娩过程正常,顺产一男婴,体重3250克,无并发症。肝素作用在使用硫酸鱼精蛋白逆转三小时前。分娩后八小时重新使用肝素。患者未出现其他并发症,产后九天出院。对该主题的文献进行了综述。特别强调了针对此类导致高凝性和血栓栓塞现象疾病的治疗选择。这是墨西哥文献中的首例报告。

相似文献

1
[Hereditary antithrombin III deficiency. Report of an obstetric case and review of the literature].[遗传性抗凝血酶III缺乏症。1例产科病例报告及文献复习]
Ginecol Obstet Mex. 1996 Apr;64:177-83.
2
Hereditary antithrombin III deficiency and pregnancy: report of two cases and review of the literature.遗传性抗凝血酶III缺乏症与妊娠:两例报告及文献复习
Obstet Gynecol. 1985 Jun;65(6):848-53.
3
Hereditary deficiency of antithrombin III, protein C and protein S: prevalence in patients with a history of venous thrombosis and criteria for rational patient screening.抗凝血酶III、蛋白C和蛋白S的遗传性缺乏:有静脉血栓形成病史患者中的患病率及合理的患者筛查标准。
Blood Coagul Fibrinolysis. 1992 Oct;3(5):547-53.
4
[Pregnancy and delivery in type II hereditary antithrombin deficient patients].[II型遗传性抗凝血酶缺乏患者的妊娠与分娩]
Cas Lek Cesk. 2008;147(10):535-7.
5
[Hereditary deficit of antithrombin III].[抗凝血酶III遗传性缺陷]
Ann Med Interne (Paris). 1986;137(6):461-4.
6
[Management with antithrombin III concentrate in a pregnant woman with hereditary antithrombin III deficiency].
Rinsho Ketsueki. 1990 Sep;31(9):1544-7.
7
Protein C deficiency and pregnancy: a case report.蛋白C缺乏与妊娠:一例报告
Obstet Gynecol. 1989 Mar;73(3 Pt 2):455-6.
8
[Anesthetic management for cesarean delivery in a pregnant patient with congenital antithrombin III deficiency and pulmonary thromboembolism].[先天性抗凝血酶III缺乏合并肺血栓栓塞症的孕妇剖宫产麻醉管理]
Rev Esp Anestesiol Reanim. 2001 Jun-Jul;48(6):285-7.
9
[Therapeutic management of pregnancy complicated by congenital antithrombin III deficiency associated with pregnancy nephropathy].妊娠合并先天性抗凝血酶III缺乏症伴妊娠肾病的治疗管理
J Gynecol Obstet Biol Reprod (Paris). 1986;15(3):299-304.
10
Familial antithrombin III deficiency.家族性抗凝血酶III缺乏症
Q J Med. 1982;51(204):373-95.

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Vena cava thrombosis associated with nephrotic syndrome in the puerperal gestational cycle.产褥期妊娠周期中与肾病综合征相关的腔静脉血栓形成
Sao Paulo Med J. 2001 Jan 4;119(1):24-8. doi: 10.1590/s1516-31802001000100007.