Tang Yunzhao, Yan Tiantian, Wang Gang, Chen Yijun, Zhu Yanjuan, Jiang Zhenhuan, Yang Min, Li Chenguang, Li Zhu, Yu Ping, Wang Shanshan, Zhu Nannan, Ren Qiuyue, Ni Changlin
Key Laboratory of Hormones and Development (Ministry of Health), Tianjin Key Laboratory of Metabolic Diseases, Tianjin Metabolic Diseases Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.
Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Int J Endocrinol. 2017;2017:1617458. doi: 10.1155/2017/1617458. Epub 2017 Oct 12.
The present study explored the association between insulin resistance (IR) and the clinical characteristics of thyroid nodules in patients with type 2 diabetes mellitus (T2DM).
All the patients were newly diagnosed with T2DM. 201 patients with thyroid nodule disease and 308 patients without the nodular thyroid disease. The participants were evaluated by relevant examination. Correlation analyses and regression analyses were performed to examine the relationships between the two groups.
HOMA-IR values, serum FT4 (free thyroxine) levels, and age were higher in the thyroid nodule group than in the control group. The proportion of women in the thyroid nodule group is greater than the proportion of women in the control group. Logistic regression analysis showed that age, sex, FT4, and HOMA-IR were positive factors for thyroid nodule. The volume and size of the thyroid nodule were positively correlated with HOMA-IR, irrespective of gender. The thyroid nodule volume and size and the TSH (thyroid stimulating hormone) were greater in females than in males, whereas FT3 (free triiodothyronine) was lower in females.
IR might be a risk factor for thyroid nodule. Whether alleviating the IR might slow the growth, or diminish the volume and size of the thyroid nodules, is yet to be elucidated.
本研究探讨2型糖尿病（T2DM）患者胰岛素抵抗（IR）与甲状腺结节临床特征之间的关联。
所有患者均为新诊断的T2DM患者。201例患有甲状腺结节疾病，308例无甲状腺结节疾病。对参与者进行相关检查。进行相关性分析和回归分析以检验两组之间的关系。
甲状腺结节组的稳态模型评估胰岛素抵抗（HOMA-IR）值、血清游离甲状腺素（FT4）水平和年龄均高于对照组。甲状腺结节组女性比例高于对照组。逻辑回归分析表明，年龄、性别、FT4和HOMA-IR是甲状腺结节的阳性因素。无论性别如何，甲状腺结节的体积和大小与HOMA-IR呈正相关。女性的甲状腺结节体积和大小以及促甲状腺激素（TSH）均大于男性，而女性的游离三碘甲状腺原氨酸（FT3）较低。
IR可能是甲状腺结节的一个危险因素。减轻IR是否会减缓甲状腺结节的生长或减小其体积和大小，尚有待阐明。
