AmirAhmadi Maryam, Moaatamedfar Azim, Moradi Leila, Taheri Hamed, Taheri Hossein
School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Radiology Department, School of Medicine, Ahvaz Jondi Shapour University of Medical Sciences, Ahvaz, Iran.
Adv Biomed Res. 2025 Apr 30;14:33. doi: 10.4103/abr.abr_499_23. eCollection 2025.
The purpose of this work was to assess insulin resistance (HOMA-IR) and metabolic syndrome prevalency among patients with and without thyroid nodules.
This case-control study was done on 86 patients with normal TSH level (0.5-4.5 mIU/L) and thyroid nodules, who referred to Imam Khomeini Hospital (Ahvaz, Iran). Besides, 43 non-nodule patients with normal TSH level and normal thyroid ultrasonic images were enrolled randomly from the general population as the control group. The parameters of metabolic syndrome including height, weight, hip circumference, waist circumference (WC), body mass index (BMI), and persistence of high blood pressure were assessed in two groups. The fasting blood sugar (FBS), total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and insulin levels were measured. The diagnosis of insulin resistance was made when the homeostasis model assessment of insulin resistance (HOMA-IR) index was ≥2.5.
The mean value of insulin resistance was considerably higher in nodule patients than the control group (3.02 ± 1.92 vs. 1.10 ± 1.55; < 0.001). HOMA-IR was seen in 49 (57.0%) and 4 (9.3%) in thyroid nodule and the control group patients, respectively ( < 0.0001). WC, BMI, FBS, TG, TC, LDL-C, HDL-C, and insulin levels were significantly higher in the nodular group than the control group.
Our study illustrates that there is an association between HOMA-IR and thyroid nodules. The thyroid nodules patients have higher HOMA-IR value compared to other groups. Also, the most of metabolic syndrome parameters were considerably higher in the thyroid nodule group.
本研究旨在评估有甲状腺结节和无甲状腺结节患者的胰岛素抵抗（HOMA-IR）及代谢综合征患病率。
本病例对照研究纳入了86例促甲状腺激素（TSH）水平正常（0.5 - 4.5 mIU/L）且有甲状腺结节的患者，这些患者均转诊至伊玛目霍梅尼医院（伊朗阿瓦士）。此外，从普通人群中随机选取43例TSH水平正常且甲状腺超声图像正常的无结节患者作为对照组。对两组患者的代谢综合征参数进行评估，包括身高、体重、臀围、腰围（WC）、体重指数（BMI）以及高血压持续情况。测量空腹血糖（FBS）、总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）和胰岛素水平。当胰岛素抵抗稳态模型评估（HOMA-IR）指数≥2.5时，诊断为胰岛素抵抗。
结节患者的胰岛素抵抗平均值显著高于对照组（3.02 ± 1.92 vs. 1.10 ± 1.55；P < 0.001）。甲状腺结节组和对照组患者中，分别有49例（57.0%）和4例（9.3%）出现HOMA-IR（P < 0.0001）。结节组的WC、BMI、FBS、TG、TC、LDL-C、HDL-C和胰岛素水平显著高于对照组。
我们的研究表明，HOMA-IR与甲状腺结节之间存在关联。与其他组相比，甲状腺结节患者的HOMA-IR值更高。此外，甲状腺结节组的大多数代谢综合征参数也显著更高。
