Hiller N, Sonnenblick M, Hershko C
Department of Medicine, Shaare Zedek Medical Center, Jerusalem, Israel.
Oncology. 1989;46(1):45-8. doi: 10.1159/000226679.
Humoral hypercalcemic syndrome associated with tumors of the female reproductive system is believed to be uncommon, and only 27 such cases have been identified prior to 1980. We describe 2 patients with humoral hypercalcemia in clear cell adenocarcinoma of the uterus, and review the literature on previously published cases. Both our patients fulfilled the criteria for humoral hypercalcemic syndrome, namely: hypercalcemia without bone metastases ranging from 12.8 to 14.1 mg/dl in the presence of normal serum parathyroid hormone levels, reduced tubular reabsorption of phosphate, and reduced serum albumin. We propose that humoral hypercalcemia is perhaps not a rare complication of uterine malignancy and, that increased awareness may result in early diagnosis of this important metabolic problem.
与女性生殖系统肿瘤相关的体液性高钙血症综合征被认为并不常见，在1980年之前仅确诊了27例此类病例。我们描述了2例子宫透明细胞腺癌伴体液性高钙血症的患者，并回顾了此前发表的相关病例文献。我们的两名患者均符合体液性高钙血症综合征的标准，即：在血清甲状旁腺激素水平正常的情况下，无骨转移的高钙血症，血钙范围为12.8至14.1mg/dl，肾小管对磷酸盐的重吸收减少，血清白蛋白降低。我们认为，体液性高钙血症可能并非子宫恶性肿瘤的罕见并发症，提高认识可能有助于早期诊断这一重要的代谢问题。
