Jian Chaohui, Xu Yiting, Ma Xiaojing, Shen Yun, Wang Yufei, Bao Yuqian
Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Clinical Center for Diabetes, Shanghai Key Clinical Center for Metabolic Disease, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai 200233, China.
Int J Endocrinol. 2020 May 16;2020:7982107. doi: 10.1155/2020/7982107. eCollection 2020.
Accumulating evidence has shown that neck circumference (NC) is associated with obesity-related metabolic abnormalities. Nonalcoholic fatty liver disease (NAFLD) is regarded as a liver manifestation of metabolic syndrome. This study aimed to investigate the relationship between NC and liver fat content (LFC) and NAFLD.
A total of 1698 subjects (577 men and 1121 women) from the Shanghai community were enrolled. All the subjects underwent NC measurement and biochemical measurements. LFC was calculated using the parameters from abdominal ultrasound images. Elevated NC was defined as NC ≥38.5 cm in men and NC ≥34.5 cm in women.
Subjects with NAFLD based on the LFC measurement had higher values of NC, liver enzyme profiles, homoeostasis model assessment-insulin resistance index, and LFC than those without NAFLD (all < 0.05), irrespective of sex. NC showed an upward trend with the increase of LFC in both men and women (both < 0.05). An elevated NC could identify 55.22% of men and 50.29% of women with NAFLD based on quantitative ultrasonography. The positive correlation between NC and LFC remained significant even after adjustment for central obesity (both < 0.05). After adjusting for confounding factors, the risk of NAFLD in subjects with an elevated NC was 1.52-fold higher in men (=0.036) and 2.31-fold higher in women ( < 0.001).
There was a significant and positive correlation between NC and LFC. The risk of NAFLD increased significantly in subjects with an elevated NC.
越来越多的证据表明，颈围（NC）与肥胖相关的代谢异常有关。非酒精性脂肪性肝病（NAFLD）被认为是代谢综合征的肝脏表现。本研究旨在探讨NC与肝脏脂肪含量（LFC）及NAFLD之间的关系。
纳入了来自上海社区的1698名受试者（577名男性和1121名女性）。所有受试者均进行了NC测量和生化检测。使用腹部超声图像参数计算LFC。NC升高定义为男性NC≥38.5 cm，女性NC≥34.5 cm。
基于LFC测量诊断为NAFLD的受试者，无论性别，其NC、肝酶谱、稳态模型评估-胰岛素抵抗指数和LFC值均高于无NAFLD者（均P<0.05）。男性和女性的NC均随LFC增加呈上升趋势（均P<0.05）。基于定量超声检查，NC升高可识别出55.22%的男性和50.29%的女性NAFLD患者。即使在调整中心性肥胖因素后，NC与LFC之间的正相关性仍然显著（均P<0.05）。在调整混杂因素后，NC升高的男性受试者患NAFLD的风险高1.52倍（P=0.036），女性高2.31倍（P<0.001）。
NC与LFC之间存在显著正相关。NC升高的受试者患NAFLD的风险显著增加。
