表征脑室扩大的认知正常个体的生物标志物特征。
Characterizing biomarker features of cognitively normal individuals with ventriculomegaly.
作者信息
Li Xiaofeng, Ba Maowen, Ng Kok Pin, Mathotaarachchi Sulantha, Pascoal Tharick A, Rosa-Neto Pedro, Gauthier Serge
机构信息
Department of Neurology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, PR China.
Alzheimer's Disease Research Unit, The McGill University Research Centre for Studies in Aging, McGill University, Montreal, Canada.
出版信息
Alzheimers Dement (Amst). 2017 Sep 5;10:12-21. doi: 10.1016/j.dadm.2017.08.001. eCollection 2018.
INTRODUCTION
The clinical significance of ventriculomegaly in cognitively normal elderly individuals remains unclear.
METHODS
We selected cognitively normal individuals (n = 425) from the Alzheimer's Disease Neuroimaging Initiative database and calculated Evans index (EI) based on the ratio of the frontal horn and skull diameter. We defined ventriculomegaly as EI ≥ 0.30, and the participants were stratified into EI ≥ 0.30 group and EI < 0.30 group. Neuropsychological, imaging, and fluid biomarker profiles between the two groups were then compared using regression models.
RESULTS
A total of 96 (22.5%) individuals who had ventriculomegaly performed worse on the cognitive tests; showed smaller hippocampal volume but larger caudate, cingulate, and paracentral gyrus volumes; and displayed lower positron emission tomography [F]fluorodeoxyglucose standardized uptake value ratio but higher amyloid burden represented by higher [F]florbetapir standardized uptake value ratio and lower cerebrospinal fluid amyloid β 1-42 levels compared to those without ventriculomegaly.
DISCUSSION
Asymptomatic ventriculomegaly might be an early imaging signature of preclinical Alzheimer's disease and/or normal pressure hydrocephalus.
引言
认知正常的老年人脑室扩大的临床意义仍不明确。
方法
我们从阿尔茨海默病神经影像学倡议数据库中选取了认知正常的个体（n = 425），并根据额角与颅骨直径的比值计算埃文斯指数（EI）。我们将脑室扩大定义为EI≥0.30，并将参与者分为EI≥0.30组和EI<0.30组。然后使用回归模型比较两组之间的神经心理学、影像学和体液生物标志物特征。
结果
共有96名（22.5%）脑室扩大的个体在认知测试中表现较差；海马体积较小，但尾状核、扣带回和中央旁回体积较大；与无脑室扩大的个体相比，正电子发射断层扫描[F]氟脱氧葡萄糖标准化摄取值比值较低，但淀粉样蛋白负荷较高，表现为较高的[F]氟比他派标准化摄取值比值和较低的脑脊液淀粉样蛋白β1-42水平。
讨论
无症状性脑室扩大可能是临床前阿尔茨海默病和/或正常压力脑积水的早期影像学特征。
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