Rabten Wangchuk, Margarita Cristiana, Eriksson Lars, Andersson Pher G
Department of Organic Chemistry, Stockholm University, Svante Arrhenius väg 16C, 10691, Stockholm, Sweden.
Department of Physical, Inorganic and Structural Chemistry, Stockholm University, Svante Arrhenius väg 16C, 10691, Stockholm, Sweden.
Chemistry. 2018 Feb 1;24(7):1681-1685. doi: 10.1002/chem.201704684. Epub 2018 Jan 2.
A number of cyclic dienes containing the allylsilane moiety were prepared by a Birch reduction and subjected to iridium-catalyzed regioselective and asymmetric hydrogenation, which provided chiral allylsilanes in high conversion and enantiomeric excess (up to 99 % ee). The compounds were successively used in the Hosomi-Sakurai allylation with various aldehydes employing TiCl as Lewis acid, providing adducts with two additional stereogenic centers in excellent diastereoselectivity.
通过Birch还原反应制备了一系列含有烯丙基硅烷部分的环状二烯，并对其进行铱催化的区域选择性和不对称氢化反应，以高转化率和对映体过量（高达99% ee）得到手性烯丙基硅烷。这些化合物随后在以TiCl作为路易斯酸的情况下，与各种醛进行Hosomi-Sakurai烯丙基化反应，以优异的非对映选择性提供了带有两个额外立体中心的加合物。
