三价铱阳离子催化烯丙基硅烷与β,γ-不饱和α-酮酯的Hosomi-Sakurai 反应生成γ,γ-二取代的α-酮酯。
Trityl Cation-Catalyzed Hosomi-Sakurai Reaction of Allylsilane with β,γ-Unsaturated α-Ketoester to Form γ,γ-Disubstituted α-Ketoesters.
机构信息
Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
出版信息
Molecules. 2022 Jul 24;27(15):4730. doi: 10.3390/molecules27154730.
(PhC)[BPh()]-catalyzed Hosomi-Sakurai allylation of allylsilanes with β,γ-unsaturated α-ketoesters has been developed to give γ,γ-disubstituted α-ketoesters in high yields with excellent chemoselectivity. Preliminary mechanistic studies suggest that trityl cation dominates the catalysis, while the silyl cation plays a minor role.
(PhC)[BPh()]-催化的烯丙基硅烷与β,γ-不饱和α-酮酯的Hosomi-Sakurai 加成反应已被开发出来，以高产率和优异的化学选择性得到γ,γ-二取代的α-酮酯。初步的机理研究表明，三苯甲基阳离子主导催化，而硅阳离子则起次要作用。
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