Kim J H, Cooper R A, Welty-Wolf K E, Harrell L J, Zwadyk P, Klotman M E
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710.
Rev Infect Dis. 1989 Jan-Feb;11(1):97-104.
Pseudomonas putrefaciens is an unusual cause of human disease. Since 1978 only five cases of bacteremia due to this organism have been reported. Within 12 recent months four cases of bacteremia due to P. putrefaciens were seen - two occurred in patients with chronic infections of a lower extremity, one in a patient with neutropenia, and one in a patient with fulminant septicemia and disseminated intravascular coagulation. Two of the patients had prostheses; in neither case did prosthetic infection or prosthetic failure occur. Two syndromes of bacteremic infection with P. putrefaciens are suggested. One syndrome is associated with chronic infection of a lower extremity, is fairly well tolerated, and responds to appropriate antimicrobial agents. The other syndrome is more fulminant and may be associated with severe underlying debility, liver disease, and malignancy. It is not yet known whether this is a meaningful distinction. The significance of the recent increase is the isolation of this organism is not clear at present.
腐败假单胞菌是人类疾病的一种不常见病因。自1978年以来，仅报告了5例由该菌引起的菌血症病例。在最近12个月内，发现了4例由腐败假单胞菌引起的菌血症病例——2例发生在患有下肢慢性感染的患者中，1例发生在中性粒细胞减少的患者中，1例发生在暴发性败血症和弥散性血管内凝血的患者中。2例患者有假体；但在这两例中均未发生假体感染或假体故障。提示了两种由腐败假单胞菌引起的菌血症感染综合征。一种综合征与下肢慢性感染有关，耐受性较好，对适当的抗菌药物有反应。另一种综合征更为暴发性，可能与严重的基础虚弱、肝脏疾病和恶性肿瘤有关。目前尚不清楚这是否是一个有意义的区别。最近该菌分离率增加的意义目前尚不清楚。
