a Department of Cognitive Psychology , Institute for Cognitive Science Studies , Tehran , Iran.
b Department of Psychology, Faculty of Psychology and Education , University of Tehran , Tehran , Iran.
Neuropsychol Rehabil. 2019 Sep;29(8):1273-1289. doi: 10.1080/09602011.2017.1391103. Epub 2017 Nov 21.
To examine the efficacy of cognitive rehabilitation treatment (CRT) for people with opioid use disorder who were recruited into a methadone maintenance treatment (MMT) programme. 120 male subjects were randomly assigned to (1) MMT plus CRT in two months or (2) MMT plus a control intervention. Subjects were assessed at the beginning, mid-point and post-intervention as well as at 1-, 3- and 6-month follow-up time points. : Analysis with repeated measure ANOVA showed that the CRT group performed significantly better in tests of learning, switching, processing speed, working memory and memory span. Moreover, the CRT group had significantly lower opiate use over the control group during 3-months follow-up. Analysis including only those with a history of methamphetamine use showed that the CRT group had significantly lower amphetamine use. No group differences were observed for treatment retention. : Our findings provide evidence that adding CRT as an adjunct intervention to MMT can improve cognitive performance as well as abstinence from both opiates and stimulants.
考察认知康复治疗（CRT）对参加美沙酮维持治疗（MMT）项目的阿片类药物使用障碍者的疗效。120 名男性受试者被随机分配到（1）MMT 加 CRT 两个月或（2）MMT 加对照干预。在干预开始、中点和结束时以及干预后 1、3 和 6 个月的随访时间点对受试者进行评估。：重复测量方差分析显示，在学习、转换、处理速度、工作记忆和记忆跨度测试中，CRT 组的表现明显更好。此外，在 3 个月的随访中，CRT 组的阿片类药物使用明显低于对照组。仅包括有安非他命使用史的受试者的分析表明，CRT 组的安非他命使用明显减少。在治疗保留方面，两组没有差异。：我们的研究结果提供了证据，表明将 CRT 作为 MMT 的辅助干预措施，可以提高认知表现，同时戒除阿片类药物和兴奋剂。
