Haenjohn Juthamas, Supwirapakorn Warakorn, Namyen Jatuporn
Department of Research and Applied Psychology, Faculty of Education, Burapha University, Chonburi, Thailand.
Front Psychiatry. 2025 Aug 20;16:1531443. doi: 10.3389/fpsyt.2025.1531443. eCollection 2025.
Inhibitory control (IC) deficit among substance abusers is a potential consequence of detrimental drug use and can also serve as a risk factor for drug-seeking behaviors, compromising substance abuse treatment and leading to drug relapse. This study examined the efficacy of an integrative cognitive neuropsychological program emphasizing brain response to enhance inhibitory control (ICNIC intervention program) among substance abusers.
A total of 30 substance abusers were recruited and randomly assigned to either an ICNIC training group and a non-training control group. The ICNIC training group participated in a 12-session intervention program and a regular rehabilitative program at alternative treatment centers. The control group did not receive ICNIC training, but participated in only the regular rehabilitative program. IC was assessed using self-report measures and a cognitive performance task. Data were collected at three points: before ICNIC training, after ICNIC training, and at a 3-week follow-up ICNIC training. Statistical analyses were implemented.
The primary findings showed that substance abusers exhibited greater self-reported self-efficacy of behavioral IC after the ICNIC training, as assessed by the self-report measure, Behavioral Inhibitory Control Inventory - Substance Use (BICI-SU). There were no improvements in the 'Go' or 'Stop' trial accuracy (neither within-subject improvement nor between-group difference at the post-training or follow-up periods), and SSRT reaction time (neither pre- to post-training within-subject improvement nor between-group difference at post-training or follow-up periods), as measured by Stop Signal Substance Task (SSST). Moreover, the lack of improved accuracy coincided with slower responses to 'Go' stimuli in the ICNIC training group as compared to the non-training control group. Thus, the ICNIC training improved self-reported self-efficacy in IC and, therefore, may be associated with an improved and cautious response strategies for IC paradigms, resulting in slower response times. However, these strategies did not translate to improved response accuracy during the SSRT.
The implementation of an ICNIC intervention program as a supplementary cognitive rehabilitation approach could potentially enhance self-efficacy of behavioral IC and improve response strategies among substance abusers. With further investigation, the program may be expected to contribute to an increase in cognitive control and promote behavioral changes that lead to positive therapeutic outcomes.
药物滥用者的抑制控制（IC）缺陷是有害药物使用的潜在后果，也可能成为寻求药物行为的风险因素，影响药物滥用治疗并导致药物复发。本研究考察了一种强调大脑反应以增强抑制控制的综合认知神经心理学项目（ICNIC干预项目）对药物滥用者的疗效。
共招募30名药物滥用者，并随机分为ICNIC训练组和非训练对照组。ICNIC训练组在替代治疗中心参加了一个为期12节的干预项目和一个常规康复项目。对照组未接受ICNIC训练，仅参加常规康复项目。使用自我报告测量和认知表现任务对抑制控制进行评估。在三个时间点收集数据：ICNIC训练前、ICNIC训练后以及ICNIC训练后3周的随访。进行了统计分析。
主要研究结果表明，通过自我报告测量工具“行为抑制控制量表 - 物质使用（BICI - SU）”评估，药物滥用者在ICNIC训练后表现出更高的自我报告的行为抑制控制自我效能感。通过停止信号物质任务（SSST）测量，“去”或“停”试验的准确性（训练后或随访期间组内改善情况以及组间差异）、停止信号反应时间（训练前后组内改善情况以及训练后或随访期间组间差异）均未得到改善。此外，与非训练对照组相比，ICNIC训练组对“去”刺激的反应更慢，且准确性没有提高。因此，ICNIC训练提高了自我报告的抑制控制自我效能感，可能与抑制控制范式中改善的谨慎反应策略相关，导致反应时间变慢。然而，这些策略在停止信号反应时间期间并未转化为提高的反应准确性。
实施ICNIC干预项目作为一种补充性认知康复方法，可能会提高药物滥用者行为抑制控制的自我效能感，并改善反应策略。随着进一步研究，该项目有望有助于增强认知控制，并促进导致积极治疗结果的行为改变。
