Xing Haijie, Chen Xiangdong, Han Yaofeng
Department of Otorhinolaryngology Head and Neck Surgery, Guang Ming New District People's Hospital, No.4253 Songbai rode, ShenZhen, 518106, China.
Department of Otorhinolaryngology Head and Neck Surgery, The Affiliated Xinhua Hospital, Hainan Medical College, Haikou, 570311, China.
Biol Res. 2017 Nov 21;50(1):37. doi: 10.1186/s40659-017-0142-7.
Regenerating gene IA (REGIA) plays an important role in tissue regeneration and tumors prognosis of epithelium origin. However, the role of REGIA in nasopharyngeal carcinoma (NPC) is unclear. This study aims to investigate the expression and function of REG1A in NPC.
We have found that there was 63 patients with REGIA positive expression of 155 patients in this study (40.65%). The positive expression rate of REGIA was 30.50, 44.44 and 47.83% in stage T2, T3 and T4 patients, respectively. The REGIA expression was significantly difference in T2 and T4 stage tumors or T2 and T3-T4 stage. The positive expression rate of REGIA was found to be higher in patients with cervical lymph node persistence than those with cervical lymph node complete regression. Patients with negative REGIA expression had a better overall survival and free survival than those with REGIA positive expression. In addition, according to the univariate and multivariate analysis, the REGIA expression was an independent adverse prognostic factor for NPC patients.
REGIA expression was a useful biomarker in NPC patients for assessing T stage and survival.
再生基因IA（REG1A）在上皮组织再生和肿瘤预后中发挥重要作用。然而，REG1A在鼻咽癌（NPC）中的作用尚不清楚。本研究旨在探讨REG1A在NPC中的表达及功能。
本研究发现155例患者中有63例REG1A呈阳性表达（40.65%）。T2、T3和T4期患者REG1A的阳性表达率分别为30.50%、44.44%和47.83%。REG1A表达在T2和T4期肿瘤或T2与T3 - T4期之间存在显著差异。REG1A阳性表达率在颈部淋巴结持续存在的患者中高于颈部淋巴结完全消退的患者。REG1A表达阴性的患者总生存期和无病生存期均优于REG1A阳性表达的患者。此外，单因素和多因素分析显示，REG1A表达是NPC患者独立的不良预后因素。
REG1A表达是评估NPC患者T分期和生存情况的有用生物标志物。
