Suppr超能文献

免疫功能障碍在作为理解免疫代谢范例的线粒体疾病中的新兴作用。

The emerging role of immune dysfunction in mitochondrial diseases as a paradigm for understanding immunometabolism.

机构信息

Metabolism, Infection and Immunity Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.

Department of Pediatrics, The University of Texas Health Science Center, Houston, TX, USA.

出版信息

Metabolism. 2018 Apr;81:97-112. doi: 10.1016/j.metabol.2017.11.010. Epub 2017 Nov 21.

Abstract

Immunometabolism aims to define the role of intermediary metabolism in immune cell function, with bioenergetics and the mitochondria recently taking center stage. To date, the medical literature on mitochondria and immune function extols the virtues of mouse models in exploring this biologic intersection. While the laboratory mouse has become a standard for studying mammalian biology, this model comprises part of a comprehensive approach. Humans, with their broad array of inherited phenotypes, serve as a starting point for studying immunometabolism; specifically, patients with mitochondrial disease. Using this top-down approach, the mouse as a model organism facilitates further exploration of the consequences of mutations involved in mitochondrial maintenance and function. In this review, we will discuss the emerging phenotype of immune dysfunction in mitochondrial disease as a model for understanding the role of the mitochondria in immune function in available mouse models.

摘要

免疫代谢旨在定义中间代谢在免疫细胞功能中的作用,生物能量学和线粒体最近成为关注焦点。迄今为止,关于线粒体和免疫功能的医学文献赞扬了使用小鼠模型探索这一生物学交汇点的优点。虽然实验小鼠已成为研究哺乳动物生物学的标准模型,但这种模型只是综合方法的一部分。人类拥有广泛的遗传表型,是研究免疫代谢的起点;具体来说,是线粒体疾病患者。通过这种自上而下的方法,作为模型生物的小鼠促进了对涉及线粒体维持和功能的突变的后果的进一步探索。在这篇综述中,我们将讨论线粒体疾病中免疫功能障碍的新兴表型,作为理解现有小鼠模型中线粒体在免疫功能中的作用的模型。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12ff/5866745/d509744b383f/nihms921776f1.jpg

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验