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[瘢痕疙瘩和增生性瘢痕形成的治疗方法]

[Treatment methods of keloid and hypertrophic scar formation].

作者信息

Wester J U, Pilegaard J, Hahn T

出版信息

Ugeskr Laeger. 1989 Jan 23;151(4):223-5.

PMID:2916252
Abstract

Hypertrophic scar and keloid are diagnoses based on clinical symptoms. Hypertrophic scar is an unacceptably enlarged scar, within the boundaries of the original wound; whereas keloid is an unacceptably enlarged scar infiltrating the surrounding tissue. Hypertrophic scar and keloid belong to the same category of diseases, characterized by increased collagen development. The treatments employed are compression, excision, corticosteroid injections and irradiation. New medical treatments affecting the collagen metabolism such as colchicin, beta-amino-proprionitrite (BAPN), D-penicillamine, cytostatics and prostaglandin-inhibitors have been introduced with promising results and fewer side effects.

摘要

肥厚性瘢痕和瘢痕疙瘩是基于临床症状做出的诊断。肥厚性瘢痕是在原伤口边界内出现的过度增生且无法接受的瘢痕;而瘢痕疙瘩是侵入周围组织的过度增生且无法接受的瘢痕。肥厚性瘢痕和瘢痕疙瘩属于同一类疾病,其特征是胶原蛋白过度生成。所采用的治疗方法包括压迫、切除、皮质类固醇注射和放射治疗。已引入了影响胶原蛋白代谢的新医学疗法,如秋水仙碱、β-氨基丙腈(BAPN)、D-青霉胺、细胞抑制剂和前列腺素抑制剂,这些疗法取得了有前景的效果且副作用较少。

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