低钾血症：替诺福韦治疗的一种潜在危及生命的并发症。
Hypokalemia: A potentially life-threatening complication of tenofovir therapy.
作者信息
Koratala Abhilash, Ruchi Rupam
机构信息
Division of Nephrology, Hypertension and Renal Transplantation, University of Florida, Gainesville, FL, USA.
出版信息
SAGE Open Med Case Rep. 2017 Nov 14;5:2050313X17741010. doi: 10.1177/2050313X17741010. eCollection 2017.
Tenofovir is a nucleotide analog reverse transcriptase inhibitor approved for the treatment of HIV and hepatitis B infections. It is widely prescribed and an integral part of the recommended regimens for the treatment of HIV infection in antiretroviral-naive patients. Tenofovir is implicated in renal proximal tubular dysfunction, which can be associated with Fanconi syndrome and hypokalemia. When the hypokalemia is severe, it can lead to life-threatening complications. We describe the case of a 59-year-old woman who suffered a cardiac arrest secondary to severe hypokalemia from tenofovir use.
替诺福韦是一种核苷酸类似物逆转录酶抑制剂，被批准用于治疗HIV感染和乙型肝炎感染。它被广泛处方，是初治抗逆转录病毒患者治疗HIV感染推荐方案中不可或缺的一部分。替诺福韦与近端肾小管功能障碍有关，这可能与范科尼综合征和低钾血症相关。当低钾血症严重时，可导致危及生命的并发症。我们描述了一名59岁女性的病例，她因使用替诺福韦导致严重低钾血症继发心脏骤停。
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