Department of Dermatology, Gunma University Graduate School of Medicine, Maebashi, Japan.
J Dermatol. 2018 Mar;45(3):349-352. doi: 10.1111/1346-8138.14140. Epub 2017 Nov 22.
We recently identified the efficacy and safety of a botulinum toxin (BTX)-A/B in Raynaud's phenomenon (RP) and digital ulcers (DU) in Japanese patients with systemic sclerosis (SSc). Detailed assessments of peripheral vascular disorder using angiography and dermoscopic images of nail fold capillaries have not been performed previously. This study aimed to evaluate the effect of BTX-B on SSc-associated peripheral vascular disorder. Two SSc patients who suffered with RP and DU were treated with a BTX-B injection, and thereafter the symptoms of RP were improved and DU healed in both patients. Furthermore, angiography showed an increased blood flow to the palm and fingers, and dermoscopic images of nail fold capillary changes showed improvement. These results suggest that a BTX-B injection may increase peripheral blood flow and improve RP and DU in SSc patients.
我们最近在日本系统性硬化症（SSc）患者中发现了肉毒毒素（BTX）-A/B 在雷诺现象（RP）和指端溃疡（DU）中的疗效和安全性。以前没有使用血管造影和甲襞毛细血管的皮肤镜图像对周围血管疾病进行详细评估。本研究旨在评估 BTX-B 对 SSc 相关周围血管疾病的影响。两名患有 RP 和 DU 的 SSc 患者接受了 BTX-B 注射治疗，此后两名患者的 RP 症状均得到改善，DU 愈合。此外，血管造影显示手掌和手指的血流增加，甲襞毛细血管变化的皮肤镜图像显示改善。这些结果表明，BTX-B 注射可能会增加外周血流量并改善 SSc 患者的 RP 和 DU。
