检测各种医院环境中的耐抗生素鲍曼不动杆菌：鲍曼不动杆菌感染传播的潜在来源。
Detection of antibiotic resistant Acinetobacter baumannii in various hospital environments: potential sources for transmission of Acinetobacter infections.
机构信息
Department of Environmental Health Engineering, School of Health, Isfahan University of Medical Sciences, Hezar Jerib Avenue, Isfahan, Iran.
Department of Microbiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
出版信息
Environ Health Prev Med. 2017 May 8;22(1):44. doi: 10.1186/s12199-017-0653-4.
BACKGROUND
Antibiotic resistant Acinetobacter baumannii has emerged as one of the most problematic hospital acquired pathogens around the world. This study was designed to investigate the presence of antibiotic resistant A. baumannii in various hospital environments.
METHODS
Air, water and inanimate surface samples were taken in different wards of four hospitals and analyzed for the presence of A. baumannii. Confirmed A. baumannii isolates were analyzed for antimicrobial susceptibility and also screened for the presence of three most common OXA- type carbapenemase-encoding genes.
RESULTS
A. baumannii was detected in 11% (7/64) of air samples with the highest recovery in intensive care units (ICUs). A. baumannii was also detected in 17% (7/42) and 2% (1/42) of surface and water samples, respectively. A total of 40 A. baumannii isolates were recovered and analysis of antimicrobial susceptibility showed the highest resistance towards ceftazidime (92.5%, 37/40). 85% (34/40) and 80% (32/40) of the isolates were also resistant to imipenem and gentamicin, respectively. Resistance genes analysis showed that 77.5% (31/40) strains contained OXA-23 and 5% (2/40) strains contained OXA-24, but OXA-58 was not detected in any of the strains.
CONCLUSION
Detection of antibiotic resistant A. baumannii in various samples revealed that hospital environments could act as a potential source for transmission of A. baumannii infections especially in ICUs. These results emphasize the importance of early detection and implementation of control measures to prevent the spread of A. baumannii in hospital environments.
背景
耐抗生素鲍曼不动杆菌已成为全球最具问题的医院获得性病原体之一。本研究旨在调查不同医院环境中耐抗生素鲍曼不动杆菌的存在情况。
方法
在四家医院的不同病房采集空气、水和无生命表面样本，分析鲍曼不动杆菌的存在情况。对确认的鲍曼不动杆菌分离株进行抗生素敏感性分析，并筛选三种最常见的 OXA 型碳青霉烯酶编码基因。
结果
在 11%（7/64）的空气样本中检测到鲍曼不动杆菌，重症监护病房（ICU）的回收率最高。在 17%（7/42）和 2%（1/42）的表面和水样中也检测到鲍曼不动杆菌。共回收 40 株鲍曼不动杆菌分离株，抗生素敏感性分析显示对头孢他啶的耐药率最高（92.5%，37/40）。85%（34/40）和 80%（32/40）的分离株对亚胺培南和庆大霉素也有耐药性。耐药基因分析显示，77.5%（31/40）的菌株含有 OXA-23，5%（2/40）的菌株含有 OXA-24，但没有菌株含有 OXA-58。
结论
在各种样本中检测到耐抗生素鲍曼不动杆菌，表明医院环境可能成为鲍曼不动杆菌感染传播的潜在来源，尤其是在 ICU 中。这些结果强调了早期检测和实施控制措施的重要性，以防止医院环境中鲍曼不动杆菌的传播。
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