Shimizu Yuji, Sato Shimpei, Noguchi Yuko, Koyamatsu Jun, Yamanashi Hirotomo, Higashi Miho, Nagayoshi Mako, Kadota Koichiro, Kawashiri Shin-Ya, Nagata Yasuhiro, Takamura Noboru, Maeda Takahiro
Department of Community Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki-shi, Sakamoto 1-12-4, Nagasaki, 852-8523, Japan.
Department of Cardiovascular Disease Prevention, Osaka Center for Cancer and Cardiovascular Disease Prevention, Osaka, Japan.
Environ Health Prev Med. 2017 Jul 27;22(1):62. doi: 10.1186/s12199-017-0668-x.
Asian-specific single nucleotide polymorphism (SNPs) (rs3782886) is reported to be associated with myocardial infarction; sarcopenia is reported to be associated with coronary subclinical atherosclerosis. On the other hand, short stature has been revealed as an independent risk factor for cardiovascular disease. However, no studies have reported on the association between sarcopenia and short stature nor on the impact of rs3782886 on this association.
Since reduced maximum voluntary tongue pressure against the palate (MTP) reflects one aspect of sarcopenia, we conducted a cross-sectional study of 537 community-dwelling elderly Japanese participants aged 60-89 years who had participated in a general health checkup in 2015. Short stature was defined as values at or under the 25th percentile, and reduced MTP was defined as the lowest tertile of the study population (<158.0 cm and <26.5 kPa for men, <145.0 cm and <24.1 kPa for women).
Independent of classical cardiovascular risk factors, short stature was revealed to be positively associated with reduced MTP. The adjusted-odds ratio (OR) and 95% confidence interval (CI) of reduced MTP for short stature was 1.87 (1.19, 2.94). We also found that independent of known cardiovascular risk factors, with the non-minor homo of rs3782886 taken as the reference group, the adjusted OR and 95% CI for short stature and reduced MTP of the minor homo allele were 3.06 (1.23, 7.63) and 3.26 (1.33, 8.03), respectively.
Short stature is independently associated with reduced MTP, with Asian-specific SNPs possibly playing an important role in this association.
据报道，亚洲特异性单核苷酸多态性（SNP）（rs3782886）与心肌梗死有关；据报道，肌肉减少症与冠状动脉亚临床动脉粥样硬化有关。另一方面，身材矮小已被揭示为心血管疾病的独立危险因素。然而，尚无研究报道肌肉减少症与身材矮小之间的关联，也没有报道rs3782886对这种关联的影响。
由于最大自主舌腭压力（MTP）降低反映了肌肉减少症的一个方面，我们对2015年参加普通健康检查的537名60 - 89岁的日本社区老年人进行了横断面研究。身材矮小定义为处于或低于第25百分位数的值，MTP降低定义为研究人群中最低三分位数（男性<158.0厘米且<26.5千帕，女性<145.0厘米且<24.1千帕）。
独立于经典心血管危险因素，身材矮小与MTP降低呈正相关。身材矮小的MTP降低的调整优势比（OR）和95%置信区间（CI）为1.87（1.19，2.94）。我们还发现，独立于已知心血管危险因素，以rs3782886的非次要纯合子作为参照组，次要纯合子等位基因的身材矮小和MTP降低的调整OR和95%CI分别为3.06（1.23，7.63）和3.26（1.33，8.03）。
身材矮小与MTP降低独立相关，亚洲特异性SNP可能在这种关联中起重要作用。
