Ke Chunlin, Feng Xuegang, Li Jie, Chen Siyu, Hu Xinyu
Department of Radiotherapy, Cancer Center, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350005, P.R. China.
Department of Cardio-Thoracic Surgery, 900 Hospital of The Joint Logistics Team, Fuzhou, Fujian 350025, P.R. China.
Exp Ther Med. 2022 Jun 29;24(2):540. doi: 10.3892/etm.2022.11477. eCollection 2022 Aug.
Single nucleotide polymorphism (SNP) of long noncoding RNA (lnc)RNA has been reported to be an important factor in cancer development. Recently, lncRNA homeobox transcript antisense intergenic RNA (HOTAIR) was indicated to induce tumorigenesis of several cancer types, but the association between the SNP of lncRNA HOTAIR and lung cancer susceptibility has remained undetermined. The present meta-analysis aimed to investigate the effect of HOTAIR polymorphism on susceptibility to lung cancer. The PubMed, Ovid Medline, Embase and Cochrane Library databases were thoroughly searched. Studies containing data on the incidence of lung cancer in patients with different HOTAIR SNPs were included. The Hardy-Weinberg equilibrium was analyzed to determine genotype distribution and allele frequencies. The odds ratio (OR) was pooled to evaluate the association of different SNPs with the susceptibility to lung cancer. A total of six studies comprising 1,715 patients with lung cancer and 2,745 healthy controls were finally included. A total of 4 SNPs (rs12826786, rs1899663, rs920778 and rs4759314) were reported. Analyses for all of these SNPs individually indicated that the lncRNA HOTAIR rs1899663 C>A polymorphism was a risk factor for lung cancer (dominant mode, AA+CA vs. CC: OR=0.816, 95% CI=0.707-0.942, P=0.005). The present study was the first meta-analysis investigating the association between lncRNA HOTAIR and lung cancer susceptibility. The results indicated that the lncRNA HOTAIR rs1899663 C>A polymorphism is a risk factor for lung cancer. LncRNA HOTAIR may be of value in lung cancer screening, particularly for populations with high-risk factors, as well as prognosis prediction. Future investigations are required to further clarify the intrinsic mechanism of the role of HOTAIR in the oncogenesis of lung cancer.
长链非编码RNA（lncRNA）的单核苷酸多态性（SNP）据报道是癌症发展中的一个重要因素。最近，lncRNA同源盒转录反义基因间RNA（HOTAIR）被表明可诱导多种癌症类型的肿瘤发生，但lncRNA HOTAIR的SNP与肺癌易感性之间的关联仍未确定。本荟萃分析旨在研究HOTAIR多态性对肺癌易感性的影响。对PubMed、Ovid Medline、Embase和Cochrane图书馆数据库进行了全面检索。纳入了包含不同HOTAIR SNP患者肺癌发病率数据的研究。分析Hardy-Weinberg平衡以确定基因型分布和等位基因频率。汇总比值比（OR）以评估不同SNP与肺癌易感性的关联。最终纳入了总共6项研究，包括1715例肺癌患者和2745例健康对照。共报道了4个SNP（rs12826786、rs1899663、rs920778和rs4759314）。对所有这些SNP分别进行分析表明，lncRNA HOTAIR rs1899663 C>A多态性是肺癌的一个危险因素（显性模型，AA + CA与CC相比：OR = 0.816，95% CI = 0.707 - 0.942，P = 0.005）。本研究是首个调查lncRNA HOTAIR与肺癌易感性之间关联的荟萃分析。结果表明，lncRNA HOTAIR rs1899663 C>A多态性是肺癌的一个危险因素。LncRNA HOTAIR可能在肺癌筛查中具有价值，特别是对于具有高危因素的人群，以及预后预测。未来需要进一步研究以阐明HOTAIR在肺癌发生过程中作用的内在机制。
