癌症中的HOTAIR：诊断、预后及治疗前景

Nazari Majid, Babakhanzadeh Emad, Mollazadeh Arghavan, Ahmadzade Mohadese, Mohammadi Soleimani Elham, Hajimaqsoudi Elnaz

Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, P.O. Box 64155-65117, Tehran, Yazd, Iran.

Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Cancer Cell Int. 2024 Dec 19;24(1):415. doi: 10.1186/s12935-024-03612-x.

The long non-coding RNA HOTAIR is overexpressed in many cancers and is associated with several cancer-promoting effects, including increased cell proliferation, migration and treatment resistance. HOTAIR levels correlate with tumor stage, lymph node metastasis and overall survival in patients with various types of cancer. This highlights the potential uses of HOTAIR, including early cancer detection, predicting patient outcome, identifying high-risk individuals and assisting in therapy selection and monitoring. The aim of this review is to provide a comprehensive summary of the research progress, molecular mechanisms and clinical significance of HOTAIR in various human cancers. In addition, the clinical applications of HOTAIR, such as targeted therapy, radiotherapy, chemotherapy and immunotherapy, are discussed, and relevant information on the potential future advances of HOTAIR in cancer research is provided.

长链非编码RNA HOTAIR在多种癌症中过表达，并与多种促癌效应相关，包括细胞增殖增加、迁移以及治疗抗性增强。HOTAIR水平与各类癌症患者的肿瘤分期、淋巴结转移及总生存期相关。这凸显了HOTAIR的潜在用途，包括早期癌症检测、预测患者预后、识别高危个体以及辅助治疗选择与监测。本综述旨在全面总结HOTAIR在各类人类癌症中的研究进展、分子机制及临床意义。此外，还讨论了HOTAIR的临床应用，如靶向治疗、放射治疗、化学治疗和免疫治疗，并提供了有关HOTAIR在癌症研究中潜在未来进展的相关信息。