Reproductive and Developmental Biology Laboratory, Department of Health, Animal Sciences and Food Safety, University of Milan, Milan, Italy.
Centre de Recherche en reproduction, Développement et Santé Intergénérationnelle, Département des Sciences Animales, Université Laval, Québec, Québec, Canada.
Biol Reprod. 2018 Feb 1;98(2):162-169. doi: 10.1093/biolre/iox149.
Folliculogenesis is remarkably similar in cattle and humans. In this review, we consider the known differences and provide a possible explanation for the greater success of oocyte in vitro maturation in cattle. Two different parallel processes that are critical for oocyte competence acquisition are examined. The first occurs in the follicle and in turn influences the oocyte, the second occurs within the oocyte itself and involves the gradual cessation of the transcription machinery with additional changes observable in the chromatin structure. We expect this insight to contribute to the improvement of human fertility programs based on in vitro fertilization, and particularly to the development of controlled ovarian stimulation protocols that yield more high-quality oocytes and thereby improve the clinical performance of treatments for infertility.
卵泡发生在牛和人类中非常相似。在这篇综述中，我们考虑了已知的差异，并为牛卵母细胞体外成熟的更大成功提供了可能的解释。检查了两个不同的平行过程，这两个过程对卵母细胞的获得至关重要。第一个过程发生在卵泡中，反过来又影响卵母细胞，第二个过程发生在卵母细胞本身中，涉及转录机制的逐渐停止，并且可以观察到染色质结构的额外变化。我们期望这一见解有助于改善基于体外受精的人类生育计划，特别是有助于开发控制性卵巢刺激方案，该方案可产生更多高质量的卵母细胞，从而改善不孕症治疗的临床效果。
