Costa Bruna Klein da, Passos Giordani Rodrigues Dos, Becker Jefferson, Sato Douglas Kazutoshi
Pontifícia Universidade Católica do Rio Grande do Sul, Faculdade de Medicina, Hospital São Lucas, Serviço de Neurologia, Porto Alegre RS, Brasil.
Instituto do Cérebro do Rio Grande do Sul, Porto Alegre RS, Brasil.
Arq Neuropsiquiatr. 2017 Oct;75(10):687-691. doi: 10.1590/0004-282X20170121.
Autoantibodies against myelin oligodendrocyte glycoprotein (MOG-IgG) have been reported in patients with inflammatory central nervous system disorders including isolated optic neuritis (ON). We compared our MOG-IgG ON patients with multiple sclerosis (MS) patients presenting with ON.
Among the total of 38 patients with optic neuropathies, six patients with isolated ON were MOG-IgG positive and eight patients with ON fulfilled the diagnostic criteria for MS. All MS patients were negative for MOG-IgG using a cell-based assay. When compared with the MS group, the MOG-IgG patients were older (mean 47 years), more frequently male (ratio 2:1) and had a higher frequency of bilateral and/or recurrent ON. The brain magnetic resonance imaging of all MOG-IgG positive patients was normal or had only unspecific white matter T2 lesions.
These findings suggest that MOG-IgG is a biomarker of an inflammatory demyelinating CNS disease distinct from MS.
在包括孤立性视神经炎（ON）在内的炎症性中枢神经系统疾病患者中，已报告存在抗髓鞘少突胶质细胞糖蛋白（MOG-IgG）自身抗体。我们将我们的MOG-IgG阳性视神经炎患者与表现为视神经炎的多发性硬化症（MS）患者进行了比较。
在总共38例视神经病变患者中，6例孤立性视神经炎患者MOG-IgG呈阳性，8例视神经炎患者符合MS诊断标准。所有MS患者采用基于细胞的检测方法检测MOG-IgG均为阴性。与MS组相比，MOG-IgG阳性患者年龄较大（平均47岁），男性比例更高（比例为2:1），双侧和/或复发性视神经炎的发生率更高。所有MOG-IgG阳性患者的脑磁共振成像正常或仅有无特异性的白质T2病变。
这些发现表明，MOG-IgG是一种不同于MS的炎症性脱髓鞘性中枢神经系统疾病的生物标志物。
