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拉福拉和特雷蒂亚科夫:路易发现的包涵体的命名。

Lafora and Trétiakoff: the naming of the inclusion bodies discovered by Lewy.

作者信息

Engelhardt Eliasz

机构信息

Universidade Federal do Rio de Janeiro, Unidade de Neurologia Cognitiva e do Comportamento, Instituto de Neurologia/Centro para Doença de Alzheimer -Instituto de Psiquiatria, Rio de Janeiro RJ, Brasil.

出版信息

Arq Neuropsiquiatr. 2017 Oct;75(10):751-753. doi: 10.1590/0004-282X20170116.

DOI:10.1590/0004-282X20170116
PMID:29166468
Abstract

Fritz Heinrich Jakob Lewy described, for the first time, in 1912, novel peculiar inclusions in neurons of certain brain nuclei in patients with Paralysis agitans, and compared his finding to the amyloid bodies described by Lafora one year before. Gonzalo Rodriguez Lafora studied one patient with Paralysis agitans, in 1913, and recognized, described, and depicted structures identical to those previously reported by Lewy. He was the first to acknowledge Lewy's finding, and also the first to name such inclusions after the discoverer - cuerpos intracelulares de Lewy (Lewy bodies). Konstantin Nikolaevich Trétiakoff named the inclusions he found in neurons of the substantia nigra of patients with Parkinson's disease as corps de Lewy (Lewy bodies), in 1919. Trétiakoff has unanimously received the credit for the eponym. However, Lafora's earlier description should make him deserving of the authorship of the eponym.

摘要

弗里茨·海因里希·雅各布·路易在1912年首次描述了震颤麻痹患者某些脑核神经元中的新型特殊包涵体,并将他的发现与一年前拉福拉描述的淀粉样体进行了比较。1913年,贡萨洛·罗德里格斯·拉福拉研究了一名震颤麻痹患者,识别、描述并描绘了与路易之前报告的结构相同的结构。他是第一个承认路易发现的人,也是第一个以发现者的名字命名这种包涵体的人——路易细胞内小体(路易小体)。1919年,康斯坦丁·尼古拉耶维奇·特列季亚科夫将他在帕金森病患者黑质神经元中发现的包涵体命名为路易体(Lewy bodies)。特列季亚科夫一致获得了这个以人名命名的荣誉。然而,拉福拉更早的描述应该使他有资格成为这个以人名命名的发现的作者。

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