Department of Neurology, Schlossparkklinik Berlin, Grolmanstr. 56, 10623, Berlin, Germany.
J Neural Transm (Vienna). 2013 Apr;120(4):509-16. doi: 10.1007/s00702-013-0984-2. Epub 2013 Mar 2.
During the years from 1908 until 1923, Lewy was the first to detail the pathological anatomy of Parkinson's disease, leading to his seminal contribution in 1912 describing the neuronal eosinophilic cytoplasmatic concentric inclusion bodies in the brainstem, later accomplished by more systematic investigations in 1923 (Lewy in Lewandowsky's Handbuch der Neurologie, 3. Band: Spez. Neurologie II. Springer, Berlin, pp 920-933, 1912). With the exception of a minority of cases and those that displayed postencephalitic Parkinsonism, Lewy was not able to confirm the significance of the substantia nigra. The findings of Tretiakoff in 1919 (significance of the substantia nigra in PD and coining of the term 'Corps de Lewy') have been underestimated or ignored for a long time. In a historical review on basal ganglia diseases from 1942, Lewy stressed the histological abnormalities of the basal ganglia and their diffuse distribution but not expressly the inclusion bodies, which in his former studies were unique in PD. For Lewy this finding was not a characteristic of the disease. Subsequent to his expulsion from Nazi-Germany in 1933, Lewy never resumed his research on PD. At the time of Lewy's death in 1950, the era of the Lewy bodies, Lewy-body-disease and the identification of atypical Parkinson syndrome cases had not even begun and followed much later.
从 1908 年到 1923 年，Lewy 首次详细描述了帕金森病的病理学解剖，这导致了他在 1912 年的开创性贡献，描述了脑干中神经元嗜酸性细胞质同心包涵体，后来在 1923 年通过更系统的调查得以证实（Lewy 在 Lewandowsky 的 Handbuch der Neurologie，第 3 卷：Spez. Neurologie II. Springer，Berlin，pp 920-933，1912）。除了少数病例和那些表现出脑炎后帕金森病的病例外，Lewy 无法确认黑质的重要性。Tretiaoff 在 1919 年的发现（黑质在 PD 中的意义和术语“Lewy 体”的创造）长期以来被低估或忽视。在 1942 年关于基底神经节疾病的历史回顾中，Lewy 强调了基底神经节的组织学异常及其弥漫性分布，但没有明确提到包涵体，在他以前的研究中，包涵体是 PD 的独特特征。对 Lewy 来说，这一发现不是疾病的特征。1933 年他被纳粹德国驱逐后，Lewy 从未恢复对 PD 的研究。到 1950 年 Lewy 去世时，Lewy 体、Lewy 体病和非典型帕金森综合征病例的识别时代甚至还没有开始，更不用说后来了。
