Vide Júlia, Magina Sofia
Dermatology and Venereology Service, São João Hospital Center, EPE - Porto, Portugal.
Department of Pharmacology, School of Medicine, University of Porto - Porto, Portugal.
An Bras Dermatol. 2017 Sep-Oct;92(5):668-674. doi: 10.1590/abd1806-4841.20175603.
Biological therapy has revolutionized moderate to severe psoriasis treatment. However, despite being more effective than conventional systemic treatments, some patients do not respond or lose response to biotechnological treatments or develop drug-antibodies, interfering with its safety and efficacy. There are also clinical forms of the disease and patient profiles for which is pending further scientific evidence for more sustained therapeutic interventions. The continuous and more detailed knowledge of psoriasis pathophysiology has allowed identifying new therapeutic targets, which is expected to help overcome the challenges of individualized psoriasis treatment.
生物疗法彻底改变了中重度银屑病的治疗方式。然而，尽管生物疗法比传统的全身治疗更有效，但一些患者对生物技术治疗无反应或失去反应，或者产生药物抗体，从而影响其安全性和疗效。对于某些临床疾病形式和患者特征，仍有待进一步的科学证据来支持更持久的治疗干预。对银屑病病理生理学不断深入和详细的了解，使得人们能够确定新的治疗靶点，有望有助于克服银屑病个体化治疗的挑战。
