血清降钙素原（PCT）对脓毒症患者抗生素应用的指导作用
Guiding Effect of Serum Procalcitonin (PCT) on the Antibiotic Application to Patients with Sepsis.
作者信息
Liu Yu, Yang Weize, Wei Jie
机构信息
Dept. of Emergency, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China.
出版信息
Iran J Public Health. 2017 Nov;46(11):1535-1539.
BACKGROUND
This study aimed to investigate the guiding effect of serum procalcitonin (PCT) on the antibiotic application to patients with sepsis.
METHODS
Ninety-eight patients with sepsis treated in Renmin Hospital of Wuhan University, China from 2015-2017 were enrolled. They were divided into two equal groups of control group and the observation group. Patients in the observation group received the antibiotic therapy guided by PCT while patients in the control group received the regular antibiotic therapy. The conventional indexes, prognosis and clinical effects of the two groups were compared.
RESULTS
There were no statistical significance in the differences of the Acute Physiology and Chronic Health Evaluation II (APACHE-II) scores C-reactive protein (CRP) and white blood cell count (WBC) levels between the two groups. The duration of the antibiotic application to patients in the observation group was (7.74±0.61) d which was (10.22±0.78) d shorter than that to patients in the control group. The difference was statistically significant (0.05). The Intensive Care Unit (ICU) stay time and the hospital stays of patients in the observation group were shorter than those of patients in the control group. The difference had statistical significance (0.05). The difference in 30-day-recurrence rate and 30 day-mortality of the patients in the two groups had no statistical significance. There was statistically significant difference in the comparison of the clinical effects between the two groups.
CONCLUSION
Guiding effects of the serum PCT on the application of antibiotics to patients with sepsis shorten the usage time of the antibiotics, ICU stay time and hospital stays.
背景
本研究旨在探讨血清降钙素原（PCT）对脓毒症患者抗生素应用的指导作用。
方法
选取2015年至2017年在武汉大学人民医院接受治疗的98例脓毒症患者。将他们分为对照组和观察组，每组各49例。观察组患者接受PCT指导下的抗生素治疗，而对照组患者接受常规抗生素治疗。比较两组患者的常规指标、预后及临床效果。
结果
两组患者的急性生理与慢性健康状况评分系统II（APACHE-II）、C反应蛋白（CRP）及白细胞计数（WBC）水平差异无统计学意义。观察组患者抗生素应用时间为（7.74±0.61）天，比对照组患者短（10.22±0.78）天。差异有统计学意义（P<0.05）。观察组患者的重症监护病房（ICU）住院时间和住院总时间均短于对照组患者。差异有统计学意义（P<0.05）。两组患者的30天复发率和30天死亡率差异无统计学意义。两组患者临床效果比较差异有统计学意义。
结论
血清PCT对脓毒症患者抗生素应用具有指导作用，可缩短抗生素使用时间、ICU住院时间和住院总时间。
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