Vaghef-Mehrabany Elnaz, Vaghef-Mehrabany Leila, Asghari-Jafarabadi Mohammad, Homayouni-Rad Aziz, Issazadeh Karim, Alipour Beitullah
Department of Nutrition, Biochemistry and Diet Therapy, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Clinical Nutrition, Tehran University of Medical Sciences, Tehran, Iran.
Health Promot Perspect. 2017 Mar 5;7(2):95-101. doi: 10.15171/hpp.2017.17. eCollection 2017.
Probiotics are live beneficial microorganisms which may exert hypolipidemic effects through many mechanisms. Lipid profile disturbances are frequently reported in rheumatoid arthritis (RA) patients. The objective of this study was to evaluate the effects of Lactobacillus casei on serum lipids of RA women. In the present parallel randomized double-blind placebo-controlled clinical trial, 60 RA patients were recruited and divided into 2 groups. They received either a daily capsule containing 10 CFU of L. casei 01, or identical capsules containing maltodextrin, for 8 weeks. Anthropometric parameters, dietary intake and physical activity were assessed at 2 ends of the study. Serum levels of total cholesterol (TC), high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C) and triglyceride (TG) were measured. Independent-samples t test and analysis of covariance (ANCOVA) test, and paired t test were used to test between- and within-group differences, respectively. There were no significant between- or within-group differences for demographic and anthropometric parameters, physical activity and dietary intakes, throughout the study. No statistically significant within-group changes were observed for serum lipids in either group; between-group differences were also insignificant by the end of study period (TC: -0.18 [-0.65, 0.29], P = 0.801, HDL-C: -1.66 [-19.28, 15.59], P = 0.663, LDL-C: -2.73 [-19.17, 13.73], P = 0.666, TG: 0.12 [-19.76, 20.00], P = 0.900). Lactobacillus casei 01 could not improve serum lipids in RA patients. Further studies using probiotic foods and different probiotic strains are suggested.
益生菌是活的有益微生物，它们可能通过多种机制发挥降血脂作用。类风湿性关节炎（RA）患者常出现血脂异常。本研究的目的是评估干酪乳杆菌对RA女性血清脂质的影响。在本次平行随机双盲安慰剂对照临床试验中，招募了60例RA患者并分为2组。她们分别每日服用一粒含有10CFU干酪乳杆菌01的胶囊，或服用含有麦芽糊精的相同胶囊，持续8周。在研究的两个阶段评估人体测量参数、饮食摄入和身体活动情况。测量血清总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）和甘油三酯（TG）水平。分别使用独立样本t检验和协方差分析（ANCOVA）检验以及配对t检验来检验组间和组内差异。在整个研究过程中，两组在人口统计学和人体测量参数、身体活动和饮食摄入方面均无显著的组间或组内差异。两组血清脂质均未观察到有统计学意义的组内变化；在研究期结束时，组间差异也不显著（TC：-0.18[-0.65,0.29]，P = 0.801；HDL-C：-1.66[-19.28,15.59]，P = 0.663；LDL-C：-2.73[-19.17,13.73]，P = 0.666；TG：0.12[-19.76,20.00]，P = 0.900）。干酪乳杆菌01不能改善RA患者的血清脂质。建议进一步开展使用益生菌食品和不同益生菌菌株的研究。
