钯催化的2-氯喹啉-3-甲醛与异腈的串联反应。
Palladium-catalyzed tandem reaction of 2-chloroquinoline-3-carbaldehydes and isocyanides.
作者信息
Shiri Morteza, Ranjbar Maryam, Yasaei Zahra, Zamanian Fatemeh, Notash Behrouz
机构信息
Department of Chemistry, Faculty of Physics and Chemistry, Alzahra University, Vanak, Tehran 1993893973, Iran.
出版信息
Org Biomol Chem. 2017 Dec 6;15(47):10073-10081. doi: 10.1039/c7ob02043k.
A facile domino reaction of 2-chloroquinoline-3-carbaldehydes in one and two equivalents of isocyanide has been investigated. Three-component reactions of 2-chloroquinoline-3-carbaldehydes, isocyanides and amines are also described. In this Pd-catalyzed reaction under controlled conditions, three novel types of quinoline derivatives were formed via amidation, lactamization or carbamate formation along with the formation of C-C, C-N, and C-O bonds in a one-pot procedure.
研究了2-氯喹啉-3-甲醛与一当量和两当量异腈的简便多米诺反应。还描述了2-氯喹啉-3-甲醛、异腈和胺的三组分反应。在该钯催化反应的可控条件下，通过酰胺化、内酰胺化或氨基甲酸酯形成，在一锅法中形成了三种新型喹啉衍生物，同时形成了C-C、C-N和C-O键。
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