Shiri Morteza, Ranjbar Maryam, Yasaei Zahra, Zamanian Fatemeh, Notash Behrouz
Department of Chemistry, Faculty of Physics and Chemistry, Alzahra University, Vanak, Tehran 1993893973, Iran.
Org Biomol Chem. 2017 Dec 6;15(47):10073-10081. doi: 10.1039/c7ob02043k.
A facile domino reaction of 2-chloroquinoline-3-carbaldehydes in one and two equivalents of isocyanide has been investigated. Three-component reactions of 2-chloroquinoline-3-carbaldehydes, isocyanides and amines are also described. In this Pd-catalyzed reaction under controlled conditions, three novel types of quinoline derivatives were formed via amidation, lactamization or carbamate formation along with the formation of C-C, C-N, and C-O bonds in a one-pot procedure.
研究了2-氯喹啉-3-甲醛与一当量和两当量异腈的简便多米诺反应。还描述了2-氯喹啉-3-甲醛、异腈和胺的三组分反应。在该钯催化反应的可控条件下，通过酰胺化、内酰胺化或氨基甲酸酯形成，在一锅法中形成了三种新型喹啉衍生物，同时形成了C-C、C-N和C-O键。
