Mauri Giovanni, Nicosia Luca, Xu Zhen, Di Pietro Salvatore, Monfardini Lorenzo, Bonomo Guido, Varano Gianluca Maria, Prada Francesco, Della Vigna Paolo, Orsi Franco
1 Deparmtent of interventional radiology, European istitute of oncology , Milan , Italy.
2 Postgraduate School of Radiology, Università degli Studi di Milano , Milan , Italy.
Br J Radiol. 2018 Feb;91(1083):20170641. doi: 10.1259/bjr.20170641. Epub 2018 Jan 17.
Various kinds of image-guided techniques have been successfully applied in the last years for the treatment of tumours, as alternative to surgical resection. High intensity focused ultrasound (HIFU) is a novel, totally non-invasive, image-guided technique that allows for achieving tissue destruction with the application of focused ultrasound at high intensity. This technique has been successfully applied for the treatment of a large variety of diseases, including oncological and non-oncological diseases. One of the most fascinating aspects of image-guided ablations, and particularly of HIFU, is the reported possibility of determining a sort of stimulation of the immune system, with an unexpected "systemic" response to treatments designed to be "local". In the present article the mechanisms of action of HIFU are described, and the main clinical applications of this technique are reported, with a particular focus on the immune-stimulation process that might originate from tumour ablations.
近年来，各种图像引导技术已成功应用于肿瘤治疗，作为手术切除的替代方法。高强度聚焦超声（HIFU）是一种新型的、完全非侵入性的图像引导技术，通过应用高强度聚焦超声实现组织破坏。该技术已成功应用于多种疾病的治疗，包括肿瘤性疾病和非肿瘤性疾病。图像引导消融，尤其是HIFU，最吸引人的一个方面是，据报道有可能确定一种对免疫系统的刺激作用，即对旨在“局部”治疗的意外“全身”反应。在本文中，描述了HIFU的作用机制，并报道了该技术的主要临床应用，特别关注可能源于肿瘤消融的免疫刺激过程。
