Western Australian Centre for Health and Ageing, University of Western Australia.
Western Australian Centre for Health and Ageing, University of Western Australia.
Maturitas. 2018 Jan;107:103-109. doi: 10.1016/j.maturitas.2017.11.001. Epub 2017 Nov 1.
Multiple brands of the same active ingredient may be available for the same strength, administration route and dose form. Generic brands needs to demonstrate bioequivalence to the originator brand, but the appearance of the generic and originator brands are not required to match. This variation is possible because different brands may vary in the excipients used in the formulation. Excipients are inactive ingredients, and typically make up about 90% of the formulation of an individual medication. Individual preferences or requirements may affect tolerance of particular excipients, such as the use of animal products. The different appearance of brands can affect medication management for some people. This review discusses the potential for excipients to alter the individual response to or tolerance of a medication brand.
同一活性成分的多个品牌可能具有相同的强度、给药途径和剂型。仿制药品牌需要证明与原研品牌具有生物等效性，但仿制药和原研品牌的外观不需要匹配。这种变化是可能的，因为不同的品牌可能在制剂中使用的赋形剂上有所不同。赋形剂是无活性的成分，通常占单个药物配方的约 90%。个人偏好或需求可能会影响对特定赋形剂的耐受性，例如使用动物产品。品牌的不同外观可能会影响一些人的药物管理。这篇综述讨论了赋形剂改变个体对药物品牌的反应或耐受性的可能性。
