Curtin Medical School,Building 410, Curtin University Kent Street, Bentley, WA 6102 Australia.
Curtin Medical School,Building 410, Curtin University Kent Street, Bentley, WA 6102 Australia.
Maturitas. 2018 Jan;107:33-38. doi: 10.1016/j.maturitas.2017.10.002. Epub 2017 Oct 6.
To examine the associations of various metabolites and hormones and hormone replacement therapy (HRT) with obesity.
This is a cross-sectional study of 1326 Singaporean women. A DXA-derived percent body fat (PBF) of ≥35% and percent abdominal fat (PAbdF) of >21.8% were used, respectively, to define women with general (GOb) and abdominal (AbdOb) obesity.
Higher levels of insulin and glucose, lower levels of HDL, higher levels of TC/HDL and HOMA values, and different levels of some hormones were noted only in the women with abdominal, and not general obesity. The incidence of general and abdominal obesity was higher in postmenopausal women with or without HRT, except that those who were on conjugated estradiol-only HRT had no increase in the incidence of general obesity compared with premenopausal women.
Abdominal obesity is associated with insulin resistance and with higher risks of metabolic syndrome and cardiovascular diseases, whereas general obesity is not. Abdominal obesity may predispose to a higher risk of diabetes. The onset of the menopause tends to increase the incidence of general and abdominal obesity, except that postmenopausal women on conjugated estradiol HRT appear to be relatively protected from general obesity.
探讨各种代谢物和激素以及激素替代疗法（HRT）与肥胖的关系。
这是一项对 1326 名新加坡女性的横断面研究。分别使用 DXA 衍生的体脂肪百分比（PBF）≥35%和腹部脂肪百分比（PAbdF）>21.8%来定义具有全身性（GOb）和腹部肥胖（AbdOb）的女性。
仅在患有腹部肥胖而不是全身性肥胖的女性中观察到胰岛素和葡萄糖水平升高、HDL 水平降低、TC/HDL 比值和 HOMA 值升高以及某些激素水平不同。无论是否接受 HRT，绝经后女性的全身性和腹部肥胖发生率均高于绝经前女性，但仅接受结合雌激素 HRT 的女性与绝经前女性相比，全身性肥胖的发生率没有增加。
腹部肥胖与胰岛素抵抗以及代谢综合征和心血管疾病的风险增加有关，而全身性肥胖则没有。腹部肥胖可能会增加患糖尿病的风险。绝经会增加全身性和腹部肥胖的发生率，但接受结合雌激素 HRT 的绝经后女性似乎相对不易发生全身性肥胖。
