Department of Gerontology, the people's Hospital of LeShan, LeShan, 614000, China.
The first clinical institute, ZunYi Medical University, ZunYi, 5630066, China.
BMC Endocr Disord. 2021 Nov 24;21(1):236. doi: 10.1186/s12902-021-00902-7.
The purpose of the present study was to investigate the correlation between the number of live-birth pregnancies and metabolic syndrome (MetS) in Chinese women according to menstruation history.
Registry data for all pregnancies in a cohort of 6157 Chinese women aged 40 years or older were obtained and the number of live-birth pregnancies were enumerated. We defined MetS using five criteria: impaired insulin metabolism and glucose tolerance, obesity in the abdominal area, dyslipidemia, and hypertension. Multivariate logistic regression analysis was conducted to assess potential risk factors for MetS. Postmenopausal women with three or more of live-birth pregnancies had the highest prevalence of MetS (P < 0.05).
Among the 6157 females aged 40 years or older in Luzhou city, 2143 (34.8%) participants had incident MetS. The number of live-birth pregnancies was significantly correlated with age and fasting blood glucose (FBG) level (P < 0.05). The prevalence of MetS increased with the number of live-birth pregnancies (P < 0.01), and the frequency in postmenopausal women was significantly higher than that in premenopausal women (P < 0.001). In the binary logistic regression model, menopausal status [OR = 0.343 (0.153-0.769), P < 0.001] were significantly associated with an increased risk of MetS.
The number of live-birth pregnancies is correlated with an increased risk of MetS in Chinese women aged 40 years and over, especially in postmenopausal women. Greater attention should be paid to postmenopausal women who have had multiple live-birth pregnancies with a view to intervening early to prevent related diseases.
本研究旨在根据月经史探讨中国女性活产妊娠次数与代谢综合征（MetS）的相关性。
获取了 6157 名年龄在 40 岁及以上的中国女性队列中所有妊娠的注册数据，并对活产妊娠次数进行了计数。我们使用五个标准定义 MetS：胰岛素代谢和葡萄糖耐量受损、腹部肥胖、血脂异常和高血压。采用多变量 logistic 回归分析评估 MetS 的潜在危险因素。有三次或三次以上活产妊娠的绝经后女性 MetS 患病率最高（P<0.05）。
在泸州市 6157 名 40 岁及以上的女性中，2143 名（34.8%）参与者发生了 MetS。活产妊娠次数与年龄和空腹血糖（FBG）水平显著相关（P<0.05）。MetS 的患病率随活产妊娠次数的增加而增加（P<0.01），且绝经后女性的频率明显高于绝经前女性（P<0.001）。在二元逻辑回归模型中，绝经状态[OR=0.343（0.153-0.769），P<0.001]与 MetS 风险增加显著相关。
活产妊娠次数与中国 40 岁及以上女性 MetS 风险增加相关，尤其是绝经后女性。对于多次活产妊娠的绝经后女性，应更加关注，以便早期干预，预防相关疾病。
