Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Clinical Immunology Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Ministry of Education Key Laboratory, Beijing, 100730, China.
Sci China Life Sci. 2017 Nov;60(11):1178-1190. doi: 10.1007/s11427-017-9224-6. Epub 2017 Nov 1.
Organs in our body have formed their own unique immune surveillance system that is finely tuned by in situ milieu. Sequestrated tissue-resident immune cells differ from their counterparts in circulation and participate in tissue physiological activities and the maintenance of local homeostasis. Dysregulation of regional immunity leads to organ-specific inflammatory injuries. Here we review the recent developments in the field of tissue-resident immune cells and organ-specific regional immunity, and discuss their clinical implication.
我们身体中的器官形成了自己独特的免疫监视系统，由原位微环境精细调节。被隔离的组织驻留免疫细胞与循环中的免疫细胞不同，它们参与组织生理活动和局部内稳态的维持。区域性免疫失调会导致器官特异性炎症损伤。本文综述了组织驻留免疫细胞和器官特异性区域性免疫领域的最新进展，并讨论了其临床意义。
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