组织驻留记忆T细胞的组织特异性调控
Tissue-Specific Control of Tissue-Resident Memory T Cells.
作者信息
Liu Yong, Ma Chaoyu, Zhang Nu
机构信息
Department of Microbiology, Immunology and Molecular Genetics, School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229; Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South Univeristy, Changsha, Hunan 410008, China.
Department of Microbiology, Immunology and Molecular Genetics, School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229.
出版信息
Crit Rev Immunol. 2018;38(2):79-103. doi: 10.1615/CritRevImmunol.2018025653.
Abstract
Tissue-resident memory T (TRM) cells have emerged as a major component of T cell biology. Recent investigations have greatly advanced our understanding of TRMs. Common features have been discovered to distinguish memory T cells residing in various mucosal and non-mucosal tissues from their circulating counterparts. Given that most organs and tissues contain a unique microenvironment, local signal-induced tissue-specific features are tightly associated with the differentiation, homeostasis, and protective functions of TRMs. Here, we discuss recent advances in the TRM field with a special emphasis on the interaction between local signals and TRMs in the context of individual tissue environment.
摘要
组织驻留记忆T（TRM）细胞已成为T细胞生物学的主要组成部分。最近的研究极大地推动了我们对TRM细胞的理解。已发现一些共同特征可将存在于各种黏膜和非黏膜组织中的记忆T细胞与其循环中的对应细胞区分开来。鉴于大多数器官和组织都包含独特的微环境，局部信号诱导的组织特异性特征与TRM细胞的分化、稳态及保护功能紧密相关。在此，我们讨论TRM领域的最新进展，特别强调在个体组织环境背景下局部信号与TRM细胞之间的相互作用。
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