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由细胞分子伴侣调控的病毒DNA和RNA复制子的组装与重塑。

Assembly and remodeling of viral DNA and RNA replicons regulated by cellular molecular chaperones.

作者信息

Sekiya Takeshi, Hu Yifan, Kato Kohsuke, Okuwaki Mitsuru, Kawaguchi Atsushi, Nagata Kyosuke

机构信息

Department of Infection Biology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, 305-8575, Japan.

Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan.

出版信息

Biophys Rev. 2018 Apr;10(2):445-452. doi: 10.1007/s12551-017-0333-z. Epub 2017 Nov 22.

Abstract

A variety of cellular reactions mediated by interactions among proteins and nucleic acids requires a series of proteins called molecular chaperones. The viral genome encodes relatively few kinds of viral proteins and, therefore, host-derived cellular factors are required for virus proliferation. Here we discuss those cellular proteins known as molecular chaperones, which are essential for the assembly of functional viral DNA/RNA replicons. The function of these molecular chaperones in the cellular context is also discussed.

摘要

由蛋白质和核酸之间的相互作用介导的多种细胞反应需要一系列被称为分子伴侣的蛋白质。病毒基因组编码的病毒蛋白种类相对较少,因此病毒增殖需要宿主来源的细胞因子。在这里,我们讨论那些被称为分子伴侣的细胞蛋白,它们对于功能性病毒DNA/RNA复制子的组装至关重要。还讨论了这些分子伴侣在细胞环境中的功能。

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