来自金钱松种子的氧化重排环阿尔廷型三萜类化合物。
Oxidatively rearranged cycloartane triterpenoids from the seeds of Pseudolarix amabilis.
作者信息
Guo Hui, Yao Shen, Yang Xinyi, Chen Yunfei, Chen Yan, Gong Feng, Tong Jun, Qian Junqing, Zhang Ailian, Cai Xiaohua
机构信息
a College of Pharmaceutical Science , Zhejiang University of Technology , Hangzhou , P.R. China.
b Zhejiang Forestry Coll , Sch Food & Pharmaceut Sci , Linan , P.R. China.
出版信息
Nat Prod Res. 2018 Aug;32(15):1817-1823. doi: 10.1080/14786419.2017.1405406. Epub 2017 Nov 24.
One novel and eight known oxidatively rearranged cycloartane triterpenoids were isolated from the seeds of Pseudolarix amabilis. The structure of the new isolate was elucidated on extensive spectroscopic analyses. Results indicated that pseudolarolide Q (4) exhibited strong antimicrobial activity against Gram-positive Staphylococcus aureus and Candida albicans at the MICs of 6.08 and 24.32 μM, respectively. Pseudolarolide I (2) showed the 11β-HSD1 inhibitory property at the IC value of 34.5 nM.
从金钱松种子中分离出一种新型和八种已知的氧化重排环阿尔廷烷三萜类化合物。通过广泛的光谱分析阐明了新分离物的结构。结果表明，假金钱松内酯Q（4）对革兰氏阳性金黄色葡萄球菌和白色念珠菌具有较强的抗菌活性，其最低抑菌浓度分别为6.08和24.32μM。假金钱松内酯I（2）在IC值为34.5 nM时表现出11β - 羟基类固醇脱氢酶1（11β-HSD1）抑制特性。
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