珙桐中环烷三萜及其抗病毒活性。
Cycloartane triterpenoids from Pseudolarix amabilis and their antiviral activity.
机构信息
School of Pharmacy, Fudan University, Shanghai, 201203, China.
School of Pharmacy, Fudan University, Shanghai, 201203, China.
出版信息
Phytochemistry. 2020 Mar;171:112229. doi: 10.1016/j.phytochem.2019.112229. Epub 2020 Jan 1.
Seven undescribed cycloartane triterpenoids, pseudolarnoids A-G, together with ten known ones, were isolated from the seeds of Pseudolarix amabilis (J. Nelson) Rehder. Their structures were elucidated on the basis of spectroscopic analysis, X-ray crystallography, and ECD data. Pseudolarnoids A-C are cycloartane triterpenoids with a unique 16S, 23R-spirolactone moiety. Pseudolarnoids F, G, and pseudolarolide C demonstrated potent antiviral effects on HSV-1 in vitro.
从白皮松（Pseudolarix amabilis（J. Nelson）Rehder）的种子中分离得到了七种未描述的环阿尔烷三萜类化合物，假拉罗苷 A-G，以及十种已知化合物。基于光谱分析、X 射线晶体学和 ECD 数据阐明了它们的结构。假拉罗苷 A-C 是具有独特的 16S、23R-螺内酯部分的环阿尔烷三萜类化合物。假拉罗苷 F、G 和假拉罗醇 C 对 HSV-1 具有体外抗病毒作用。
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