Chirek A, Silaghi C, Pfister K, Kohn B
Clinic for Small Animals, Faculty of Veterinary Medicine, Freie Universität Berlin, 14163, Berlin, Germany.
Comparative Tropical Medicine and Parasitoloy, Ludwig-Maximilians-Universität München, 80802, Munich, Germany.
J Small Anim Pract. 2018 Feb;59(2):112-120. doi: 10.1111/jsap.12787. Epub 2017 Nov 24.
To describe the clinical signs, laboratory results, therapy and course of disease in dogs with canine granulocytic anaplasmosis in which co-infections had been excluded.
Medical records of dogs naturally infected with Anaplasma phagocytophilum were retrospectively evaluated with regard to clinical signs and laboratory abnormalities at the time of presentation, therapy and course of disease.
Nine hundred and seventy-four dogs with clinical signs suspicious for canine granulocytic anaplasmosis were tested for A. phagocytophilum DNA by modified real-time PCR; 72 dogs had a positive result. Nine of the positive dogs were excluded from further evaluation due to other diseases or lack of data. The most common clinical signs in the 63 A. phagocytophilum-positive dogs included in the study were lethargy and reduced activity (83%), fever (67%) and inappetence (63%). Thrombocytopenia was the most common laboratory abnormality (86%), followed by increased liver enzyme activities and hyperbilirubinaemia (77%), anaemia (70%), hypoalbuminaemia (62%) and leucocytosis (27%). Of 36 thrombocytopenic dogs tested for platelet-bound antibodies, 44% were positive. Of the 63 infected dogs, 59 (97%) recovered, two dogs died (epileptic seizures and immune-mediated haemolytic anaemia) and two were lost to follow-up.
In areas where it is endemic, canine granulocytic anaplasmosis should be considered as a potential cause of acute nonspecific clinical signs or immune-mediated disease if tick exposure cannot be excluded.
描述已排除合并感染的犬粒细胞无形体病犬的临床体征、实验室检查结果、治疗及病程。
回顾性评估自然感染嗜吞噬细胞无形体的犬的病历，包括就诊时的临床体征和实验室异常、治疗及病程。
对974只临床体征疑似犬粒细胞无形体病的犬进行改良实时PCR检测嗜吞噬细胞无形体DNA；72只犬结果呈阳性。9只阳性犬因其他疾病或数据缺失被排除进一步评估。纳入研究的63只嗜吞噬细胞无形体阳性犬最常见的临床体征包括嗜睡和活动减少（83%）、发热（67%）和食欲不振（63%）。血小板减少是最常见的实验室异常（86%），其次是肝酶活性升高和高胆红素血症（77%）、贫血（70%）、低白蛋白血症（62%）和白细胞增多（27%）。36只检测血小板结合抗体的血小板减少犬中，44%呈阳性。63只感染犬中，59只（97%）康复，2只犬死亡（癫痫发作和免疫介导的溶血性贫血），2只失访。
在地方流行区，如果不能排除蜱虫暴露，犬粒细胞无形体病应被视为急性非特异性临床体征或免疫介导疾病的潜在病因。
