额颞叶痴呆的生物学、神经影像学和神经生理学标志物：同一枚硬币的三面。

Department of Clinical and Experimental Sciences, Neurology Unit, University of Brescia, Brescia, Italy.

Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy.

J Alzheimers Dis. 2018;62(3):1113-1123. doi: 10.3233/JAD-170584.

Frontotemporal dementia (FTD) is a heterogeneous clinical, genetic, and neuropathological disorder. Clinical diagnosis and prediction of neuropathological substrates are hampered by heterogeneous pictures. Diagnostic markers are key in clinical trials to differentiate FTD from other neurodegenerative dementias. In the same view, identifying the neuropathological hallmarks of the disease is key in light of future disease-modifying treatments. The aim of the present review is to unravel the progress in biomarker discovery, discussing the potential applications of available biological, imaging, and neurophysiological markers.

额颞叶痴呆（FTD）是一种异质性的临床、遗传和神经病理学疾病。临床诊断和对神经病理学基础的预测受到异质性表现的阻碍。诊断标志物是临床试验中区分 FTD 与其他神经退行性痴呆的关键。同样，鉴于未来的疾病修饰治疗，确定疾病的神经病理学特征是关键。本综述的目的是阐明生物标志物发现的进展，讨论现有生物学、影像学和神经生理学标志物的潜在应用。