对经病理证实的额颞叶痴呆综合征中β淀粉样蛋白的评估。
Assessment of amyloid β in pathologically confirmed frontotemporal dementia syndromes.
作者信息
Tan Rachel H, Kril Jillian J, Yang Yue, Tom Nicole, Hodges John R, Villemagne Victor L, Rowe Christopher C, Leyton Cristian E, Kwok John B J, Ittner Lars M, Halliday Glenda M
机构信息
Brain and Mind Centre, Sydney Medical School, The University of Sydney, Sydney, Australia.
School of Medical Sciences, University of New South Wales, Sydney, Australia.
出版信息
Alzheimers Dement (Amst). 2017 May 29;9:10-20. doi: 10.1016/j.dadm.2017.05.005. eCollection 2017.
INTRODUCTION
The diagnostic utility of in vivo amyloid β (Aβ) imaging to aid in the clinical distinction between frontotemporal dementia (FTD) and Alzheimer's disease remains unclear without data on the prevalence and severity of Aβ in pathologically confirmed FTD syndromes.
METHODS
Aβ was assessed in 98 autopsy-confirmed FTD and 36 control cases, and the pathological accuracy of C-Pittsburgh compound B (PiB)-positron emission tomography imaging was assessed in a subset of FTD cases ( = 15).
RESULTS
Aβ was identified in a similar proportion of FTD syndromes and age-matched controls and increases with age. Alzheimer's disease pathology was identified in all cases with high PiB retention and in one case with low PiB retention. We further demonstrate a strong regional correlation between volume fraction of histological Aβ with PiB standard uptake value ratio scaled to the white matter.
DISCUSSION
The present study provides a pathologic reference to assist in the interpretation of in vivo assessments in FTD syndromes.
引言
在缺乏病理确诊的额颞叶痴呆（FTD）综合征中淀粉样β蛋白（Aβ）患病率和严重程度数据的情况下，体内Aβ成像在辅助临床区分FTD和阿尔茨海默病方面的诊断效用仍不明确。
方法
对98例尸检确诊的FTD病例和36例对照病例进行Aβ评估，并在一部分FTD病例（n = 15）中评估C-匹兹堡化合物B（PiB）-正电子发射断层扫描成像的病理准确性。
结果
在FTD综合征病例和年龄匹配的对照病例中，Aβ的检出比例相似，且随年龄增加。在所有PiB高摄取保留的病例以及1例PiB低摄取保留的病例中均发现了阿尔茨海默病病理改变。我们进一步证明了组织学Aβ的体积分数与按白质缩放的PiB标准摄取值比率之间存在很强的区域相关性。
讨论
本研究提供了一个病理参考，以协助解释FTD综合征的体内评估结果。
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