Gnepp D R, Schroeder W, Heffner D
Department of Pathology, St. Louis University School of Medicine, Missouri.
Cancer. 1989 Mar 15;63(6):1219-24. doi: 10.1002/1097-0142(19890315)63:6<1219::aid-cncr2820630631>3.0.co;2-y.
Multiple separate tumors arising in the major salivary glands are distinctly unusual. The records on 25 patients with synchronous unilateral salivary gland tumors on file at St Louis University and at the Armed literature. Bilateral tumors arose more frequently than multiple unilateral ones. The most common tumors with bilateral synchronous or metachronous development are the Warthin tumors, with more than 100 reported cases; the mixed tumor with at least 34 cases; and the acinic cell carcinoma, with 12 reported cases. The Warthin tumor also was the most likely to present with multifocal unilateral involvement with 29 tumors having three or more separate foci of tumor. The next most common tumor combinations are a Warthin tumor and a mixed tumor (20 cases), the multifocal membranous basal cell adenoma (12 cases), and multiple oncocytomas (nine cases). Numerous other tumor combinations were found covering the range of salivary gland neoplasia, however one of the tumors usually was a mixed tumor or a Warthin tumor.
在大唾液腺中出现多个独立肿瘤极为罕见。圣路易斯大学和武装部队文献中存档的25例同步单侧唾液腺肿瘤患者的记录显示，双侧肿瘤比多个单侧肿瘤更常见。双侧同步或异时发生的最常见肿瘤是沃辛瘤，报告病例超过100例；混合瘤至少34例；腺泡细胞癌报告病例12例。沃辛瘤也是最有可能出现多灶性单侧受累的，有29个肿瘤有三个或更多个独立的肿瘤灶。接下来最常见的肿瘤组合是沃辛瘤和混合瘤（20例）、多灶性膜性基底细胞腺瘤（12例）和多个嗜酸性细胞瘤（9例）。还发现了许多其他肿瘤组合，涵盖了唾液腺肿瘤的范围，然而其中一种肿瘤通常是混合瘤或沃辛瘤。
