Seifert G, Donath K
Institute of Pathology, University of Hamburg, Germany.
Eur J Cancer B Oral Oncol. 1996 Jan;32B(1):3-7. doi: 10.1016/0964-1955(95)00063-1.
Multiple tumours of the salivary glands are very rare and their combinations according to histological classification of the tumours, localisation and origin (origin in independent topographical areas or in the same tissue) are diverse. The following two categories can be distinguished: common occurrence of multiple salivary gland tumours with identical histology, or with different histology. In either group the tumours can be unilateral or bilateral, synchronous or metachronous. The most common multiple tumours with an identical histology are Warthin tumours and pleomorphic adenomas. Bilateral occurrence has been observed especially in oncocytomas, acinic cell carcinomas and basal cell adenomas. In the group of multiple tumours with differing histology, Warthin tumours and pleomorphic adenomas show a number of combinations with other adenomas or carcinomas of the salivary glands. Notable also is the simultaneous occurrence of salivary gland tumours with other oral tumours or extraglandular tumours, especially thyroid carcinomas and breast carcinomas. Multiple salivary gland tumours must be distinguished by nomenclature from tumours with biphasic differentiation and hybrid tumours. Tumours with biphasic differentiation are defined as regular, recurring mixtures of two cellular components in the same tumour and have a corresponding term in the tumour classification. Hybrid tumours are very rare and are composed of two different tumour entities within the same topographical area. Each of the tumour entities conforms with an exactly defined tumour category.
涎腺多发性肿瘤非常罕见，根据肿瘤的组织学分类、定位和起源（起源于独立的解剖区域或同一组织），其组合方式多种多样。可区分以下两类：组织学相同或不同的多发性涎腺肿瘤的常见情况。在这两组中，肿瘤可以是单侧或双侧的，同时性或异时性的。组织学相同的最常见多发性肿瘤是沃辛瘤和多形性腺瘤。双侧发生尤其见于嗜酸细胞瘤、腺泡细胞癌和基底细胞腺瘤。在组织学不同的多发性肿瘤组中，沃辛瘤和多形性腺瘤与涎腺的其他腺瘤或癌有多种组合。涎腺肿瘤与其他口腔肿瘤或腺外肿瘤，尤其是甲状腺癌和乳腺癌同时发生也值得注意。多发性涎腺肿瘤必须通过命名法与具有双相分化的肿瘤和混合性肿瘤区分开来。具有双相分化的肿瘤被定义为同一肿瘤中两种细胞成分的规则、复发性混合物，并且在肿瘤分类中有相应的术语。混合性肿瘤非常罕见，由同一解剖区域内的两种不同肿瘤实体组成。每个肿瘤实体都符合一个确切定义的肿瘤类别。
