在抗原刺激部位持续释放的细胞生长抑制剂可增强细胞介导的免疫。
Cell-mediated immunity is enhanced by cytostatic drugs continuously released at the site of antigenic stimulation.
作者信息
Claessen A M, Valster H, Bril H, Meyer S, Scheper R J
机构信息
Department of Pathology, Free University Hospital, Amsterdam, the Netherlands.
出版信息
Cancer Immunol Immunother. 1989;28(2):131-5. doi: 10.1007/BF00199113.
Immunopotentiation by cytostatic drugs continuously released from osmotic minipumps, was investigated in a guinea-pig contact-sensitivity model. These pumps are designed to release their content within a period of 7 days. Vepeside (VP-16) and 5-fluorouracil were released into oxazolone-stimulated lymph nodes by subcutaneous implantation of pumps containing either of these drugs. The pumps were implanted at the intended sensitization site, 2 days before sensitization. Strong potentiation of T-cell-mediated immunity, evaluated by delayed-type hypersensitivity measurements, was observed with both drugs tested. Daily injections with VP-16 also caused an enhancement of the immune response. However, daily injections with 5-fluorouracil, a drug assumed to be cell-cycle-specific in its action, failed to potentiate delayed hypersensitivity to oxazolone. Intralesional administration of cytostatic drugs has been put forward as an effective treatment modality in various types of cancer. Therapeutic effects may depend on both local tumor cytotoxic and immunopotentiating activities. Our present results suggest that osmotic minipumps can be applied to broaden the applicability and effectiveness of local chemotherapy.
在豚鼠接触性敏感模型中，研究了从渗透微型泵持续释放的细胞抑制药物的免疫增强作用。这些泵被设计为在7天内释放其内容物。通过皮下植入含有依托泊苷（VP-16）或5-氟尿嘧啶的泵，将这两种药物释放到恶唑酮刺激的淋巴结中。泵在致敏前2天植入预期的致敏部位。通过迟发型超敏反应测量评估，两种受试药物均观察到T细胞介导的免疫有强烈增强。每日注射VP-16也导致免疫反应增强。然而，每日注射5-氟尿嘧啶（一种假定其作用具有细胞周期特异性的药物）未能增强对恶唑酮的迟发型超敏反应。在各种类型的癌症中，瘤内注射细胞抑制药物已被提出作为一种有效的治疗方式。治疗效果可能取决于局部肿瘤细胞毒性和免疫增强活性。我们目前的结果表明，渗透微型泵可用于拓宽局部化疗的适用性和有效性。
Zotero 插件