局部给药的细胞抑制药物与一种表面活性剂对小鼠对钥孔戚血蓝蛋白迟发型超敏反应发展的协同作用。
Synergistic effects of locally administered cytostatic drugs and a surfactant on the development of delayed-type hypersensitivity to keyhole limpet haemocyanin in mice.
作者信息
Limpens J, Scheper R J
出版信息
Clin Exp Immunol. 1989 Nov;78(2):256-62.
The immunomodulating effects of two locally administered cytostatic drugs, the active cyclophosphamide-derivative Z 7557 and the plant alkaloid VP-16, were compared with the effects of systemically administered cyclophosphamide and several established adjuvants: Freund's complete adjuvant, dextran sulphate, and dimethyl dioctadecyl ammonium bromide (DDA). All agents tested promoted the development of delayed-type hypersensitivity (DTH) to keyhole limpet haemocyanin (KLH) in mice. Locally administered cytostatic drugs were the most effective immunostimulatory compounds, whereas DDA was the least toxic agent tested. In order to increase the effectiveness and/ or reduce the toxicity of these agents we tested the efficacy of combinations of cytostatic drugs and DDA to enhance DTH. The results show that DDA and suboptimal amounts of locally administered cytostatic drugs act synergistically on DTH.
比较了两种局部给药的细胞抑制药物（活性环磷酰胺衍生物Z 7557和植物生物碱VP-16）与全身给药的环磷酰胺以及几种既定佐剂（弗氏完全佐剂、硫酸葡聚糖和二甲基二十八烷基溴化铵（DDA））的免疫调节作用。所有测试药物均促进了小鼠对钥孔戚血蓝蛋白（KLH）的迟发型超敏反应（DTH）的发展。局部给药的细胞抑制药物是最有效的免疫刺激化合物，而DDA是测试药物中毒性最小的。为了提高这些药物的有效性和/或降低其毒性，我们测试了细胞抑制药物与DDA联合使用增强DTH的效果。结果表明，DDA与局部给药的亚最佳剂量细胞抑制药物对DTH具有协同作用。
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