Department of Radiation Oncology, University of North Carolina School of Medicine, Chapel Hill, NC; Lineberger Comprehensive Cancer Center, University of North Carolina Hospitals, Chapel Hill, NC.
Department of Radiation Oncology, University of Florida Hospitals, Gainesville, FL; Shands Cancer Center, University of Florida Hospitals, Gainesville, FL.
Semin Radiat Oncol. 2018 Jan;28(1):27-34. doi: 10.1016/j.semradonc.2017.08.001.
The prevalence of patients with human papilloma virus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) is rapidly increasing, and it is now well known that these patients have a significantly better prognosis than patients with HPV-negative OPSCC. Though standard treatments result in excellent cancer control, they are also associated with substantial long-term toxicity. There is now great interest in evaluating less intensive (ie, deintensified) treatment regimens to improve the therapeutic ratio (maintain excellent cancer control and decrease toxicity). There are many different approaches that are being studied, and each have their own caveats, with varying degrees of actual deintensification. In this article, we critically review the current landscape of emerging deintensified treatment paradigms and future direction of the treatment of HPV-associated OPSCC.
人乳头瘤病毒（HPV）相关口咽鳞状细胞癌（OPSCC）患者的发病率正在迅速上升，现在众所周知，这些患者的预后明显优于 HPV 阴性 OPSCC 患者。尽管标准治疗可获得极佳的癌症控制效果，但也会引起严重的长期毒性。因此，人们现在非常关注评估强度较低（即减量化）的治疗方案，以改善治疗效果（保持优异的癌症控制效果并降低毒性）。目前正在研究许多不同的方法，每种方法都有其自身的注意事项，实际减量化程度也各不相同。在本文中，我们批判性地回顾了新兴减量化治疗模式的现状以及 HPV 相关 OPSCC 治疗的未来方向。
