Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Department of Periodontology, National Taiwan University Hospital, Taipei, Taiwan; Division of Periodontology, Department of Dentistry, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan.
Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Department of Periodontology, National Taiwan University Hospital, Taipei, Taiwan.
J Formos Med Assoc. 2018 Nov;117(11):1003-1010. doi: 10.1016/j.jfma.2017.11.006. Epub 2017 Nov 22.
BACKGROUND/PURPOSE: Chronic periodontitis (CP) and rheumatoid arthritis (RA) are the most common chronic inflammatory diseases and their immunopathogenesis is similar. The aim of this study was to evaluate the effect of non-surgical periodontal treatment on the serum levels of RA-related inflammatory markers in patients with chronic periodontitis.
Thirty-one Taiwanese adults with CP were included. Demographics and periodontal parameters, including probing depth, clinical attachment level, and number of remaining teeth in the oral cavity, were recorded. All subjects received non-surgical periodontal treatment such as scaling and subgingival root planing. Serum samples were collected before and after the treatment. Serum levels of anti-citrullinated protein antibodies (ACPA), rheumatoid factor, tumor necrosis factor-α (TNF-α), C-reactive protein, interleukin-1β (IL-1β), and Interleukin-6 (IL-6) were measured using an enzyme-linked immunosorbent assay.
Non-surgical periodontal treatment significantly reduced the serum ACPA (p = 0.015) and TNF-α levels (p = 0.026) in CP patients, particularly in patients with generalized CP. Furthermore, there was a significant and positive correlation between the number of extracted teeth and the reduction in the serum ACPA (p = 0.05) and IL-1β levels (p = 0.029) after non-surgical periodontal treatment.
Non-surgical periodontal therapy may aid in the control of RA-related inflammatory markers in patients with CP. A large-scale study with well-defined populations is needed to clarify the benefit of non-surgical periodontal therapy.
背景/目的：慢性牙周炎（CP）和类风湿关节炎（RA）是最常见的慢性炎症性疾病，其免疫发病机制相似。本研究旨在评估非手术性牙周治疗对慢性牙周炎患者血清 RA 相关炎症标志物水平的影响。
纳入 31 名台湾成年人 CP 患者。记录人口统计学和牙周参数，包括探诊深度、临床附着水平和口腔内剩余牙齿数。所有患者均接受非手术性牙周治疗，如洁治和龈下根面平整。治疗前后采集血清样本。采用酶联免疫吸附试验检测血清抗瓜氨酸蛋白抗体（ACPA）、类风湿因子、肿瘤坏死因子-α（TNF-α）、C 反应蛋白、白细胞介素-1β（IL-1β）和白细胞介素-6（IL-6）水平。
非手术性牙周治疗可显著降低 CP 患者的血清 ACPA（p=0.015）和 TNF-α水平（p=0.026），尤其是广泛性 CP 患者。此外，非手术性牙周治疗后，拔牙数与血清 ACPA（p=0.05）和 IL-1β水平（p=0.029）的降低呈显著正相关。
非手术性牙周治疗可能有助于控制 CP 患者的 RA 相关炎症标志物。需要进行具有明确人群的大规模研究，以阐明非手术性牙周治疗的益处。
